Clinical rationale for the use of autologous platelet-rich plasma during cesarean section

The use of autologous platelet-rich plasma (aPRP) is one of the modern methods to model tissue regeneration, which promotes acceleration of scar formation, activation of collagenization and angiogenesis, and maturation of connective tissue. Objective. To evaluate the therapeutic efficiency of intraoperative aPRP use for intensifying the mechanism of reparative wound regeneration after cesarean section (CS). Subjects and methods. Fifty pregnant women who had undergone surgical delivery participated in the investigation. During the latter, the patients were randomized into 2 groups according to the type of surgery: 1) standard CS; 2) CS using aPRP. Clinical, laboratory, and instrumental studies were applied. Results. The incorporation of aPRP during CS has been shown to be an easy-to-use method that does not increase the duration of surgical therapy and significantly reduces blood loss by 26.3% (p>0.05). The use of aPRP in the early stages of CS is accompanied by a decrease in peripheral vascular resistance and by an improvement in blood flow, which leads to the stimulation of wound regenerative processes, to the intensification of angiogenesis, to the acceleration of tissue remodeling, to a reduction in the phase of wound healing, and, as a result, to a lower incidence of pyoseptic complications. Conclusion. aPRP can be used during CS to reduce the risk of pyoseptic complications and to create an optimal and adequate uterine scar.