HUMAN SPERM CHROMATIN STRUCTURES AND DNA FRAGMENTATION IN HEALTH AND INFERTILITY

The main method for the examination of infertile males is to study the indicators of sperm, such as its concentration and amount, mobility and morphology. Although these indicators are generally higher in fertile men than in infertile ones, there may be their substantial coincidence, suggesting some factors that are ignored during traditional spermiological examination. Complementary tests provide a way of investigating the function of the sperm components responsible for both conception proper and involvement in the epigenetic regulation of early embryogenesis. In the light of the wide introduction of assisted reproductive technologies (ART) into clinical practice, of particular interest is the structure of the genetic material proper - the nucleus of a spermatozoon (structure, DNA fragmentation, anomalies of chromatin and its package), whose abnormalities may give rise to infertility and ART failures.

TUNEL, fertility, DNA fragmentation, EMIS, TUNEL, infertility, sperm chromatin, spermiogenesis