PROGNOSTIC VALUE OF PROINFLAMMATORY CYTOKINES IN CHRONIC VIRAL HEPATITIS B AND C


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详细

The increased production of tumor necrosis factor-α and interleukin-6 in patients with chronic viral hepatitis B and C has been established to contribute to the worsening damage to the liver and the development of its fibrosis. There is evidence that the above proinflammatory cytokines may be used as an additional diagnostic criterion for the course and prognosis (the development of fibrosis) in the disease in question.

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作者简介

E. Stilldl

S.I. Georgievsky Crimean State Medical University, Simferopol, Ukraine

Email: aleandreeva1@gmail.com

I. Klyaritskaya

S.I. Georgievsky Crimean State Medical University, Simferopol, Ukraine

Email: aleandreeva1@gmail.com

参考

  1. Lavanchy D. Evolving epidemiology of hepatitis C virus // Clin. Microbiol. Infect. - 2011; 17: 107-15.
  2. Wursthorn K., Wedemeyer H., Manns M. Republished paper: Managing HBV in patients with impaired immunity // Postgrad. Med. J. - 2011; 87: 223-38.
  3. Li K., Li N., Wei D. et al. Activation of chemokine and inflammatory cytokine response in hepatitis C virus-infected hepatocytes depends on Toll-like receptor 3 sensing of hepatitis C virus double-stranded RNA intermediates // Hepatology. -2012; 55 (3): 666-75.
  4. Chen J., Wang Y., Wu X. et al. Down-regulation of PD-1 expression on lymphocytes in chronic hepatitis B patients with pegylated interferon а^ treatment and the correlation with cytokines // J. Hepatol. - 2010; 52 (1): 239-40.
  5. Kasprzak A., Seidel J., Spachacz R. et al. Intracellular expression of proinflammatory cytokines (IL-1 alpha, TNF-alpha, and IL-6) in chronic hepatitis // Rocz. Akad. Med. Bialymst. - 2004; 49 (2): 207-9.
  6. Falleti E., Fabris C., Toniutto P. et al. Genetic polymorphisms of inflammatory cytokines and liver fibrosis progression due to recurrent hepatitis C // Int. Cyt. Res. - 2007; 27 (3): 239-46.
  7. Mishra P., Bhargava A., Vashistha P. et al. Mediators of the immune system and their possible role in pathogenesis of chronic hepatitis B and C viral infections // AsPac. J. Mol. Biol. Biotechnol. - 2010; 18 (3): 341-9.
  8. Farci P., Wollenberg K., Diaz G. et al. Profibrogenic chemokines and viral evolution predict rapid progression of hepatitis C to cirrhosis // Proc. Natl. Acad. Sci. USA. - 2012; 109: 14562-7.
  9. Никитин В.Ю., Сухина И.А., Цыган В.Н. и др. Спектр цитокинов крови больных хроническим гепатитом С на различных стадиях заболевания // Мед. иммунол. - 2007; 9 (2-3): 236-7.
  10. Коротчаева Ю.В., Самоходская Л.М., Сперанский А.И. и др. Прогностическое значение определения ИЛ-6 в сыворотке крови и цитохрома Р450 в ткани печени у больных хроническим гепатитом С // Рос. журн. гастроэнтерол., гепатол., колопроктол. - 2008; 2 (18): 42-7.
  11. Huang Y., Hwang S., Chan C. et al. Serum levels of cytokines in hepatitis C -related liver disease: a longitudinal study // Zhonghua Yi Xue Za Zhi (Taipei). -1999; 62: 327-33.
  12. Lapinski T. The levels of cytokines in HCV patients // Arch. Immunol. Ther. Exp. - 2001; 49: 311-6.
  13. Филимонов П.Н., Гаврилова Н.И., Сухенко Т.Г. Уровень фактора некроза опухоли-а в сыворотке и степень фиброза печени у детей с хроническим вирусным гепатитом В, С и В+С при лечении интерфероном-а // Журн. микробиол., эпидемиол. и иммунобиол. - 2002; 2: 69-72.

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