A GENETIC PREDICTOR OF IMMEDIATE HYPERSENSITIVITY REACTIONS CAUSED BY β-LACTAM ANTIBIOTICS

作者: Chlkalo A.¹, Groznova I.¹, Ismagllov T.¹, Berdnikova N.¹, Sychev D.¹, Kukes V.¹
隶属关系:
1. Research Center for Examination of Medical Products, Moscow, Russia
期: 卷 24, 编号 3 (2013)
页面: 87-88
栏目: Articles
URL: https://journals.eco-vector.com/0236-3054/article/view/115737
ID: 115737

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The paper presents the results of genotyping of a Russian patient population by the polymorphic marker rs2243250 of the promotor region of the IL4 gene to determine whether this polymorphism can be used as a predictor for immediate hypersensitivity reactions to β-lactam antibiotics.

关键词

rs2243250, β-lactam antibiotics, adverse reactions, genetic predictors, IL4, rs2243250

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作者简介

A. Chlkalo

Research Center for Examination of Medical Products, Moscow, Russia

Email: doltshpir@gmail.com

I. Groznova

Research Center for Examination of Medical Products, Moscow, Russia

Email: doltshpir@gmail.com

T. Ismagllov

Research Center for Examination of Medical Products, Moscow, Russia

Email: doltshpir@gmail.com

N. Berdnikova

Research Center for Examination of Medical Products, Moscow, Russia

Email: doltshpir@gmail.com

D. Sychev

Research Center for Examination of Medical Products, Moscow, Russia

Email: doltshpir@gmail.com

V. Kukes

Research Center for Examination of Medical Products, Moscow, Russia

Email: doltshpir@gmail.com

参考

Практическое руководство по антиинфекционной химиотерапии. Под ред. Л.С. Страчунского, Ю.Б. Белоусова, С.Н. Козлова // Смоленск: МАКМАХ, 2007; 464 с.
Яриллин А.А. Основы иммунологии / М.: Медицина. - 1999; 655 с.
Драник Г.Н. Клиническая иммунология и аллергология // М.: Астропринт. - 1999; 603 с.
Патрушев Л.И. Генная и белковая инженерия // М.: Наука. - 2004; 214 с.
Liu H.H. Antibiotics and infectious diseases // Primary Care. - 1990; 17 (4): 745-74.
Gerald P. Penicillins, Monobactams, and Carbapenems // Texas Heart Inst. J. - 1990; 17 (4): 319-25.
Baye T., Butsch M., Biagini M. et al. Differences in candidate gene association between European ancestry and African American asthmatic children // PLoS One. - 2011; 6 (2): e16522.
Kim S., Lee J., Kim S. et al. Adverse Drug Reaction Research Group in Korea. Allelic variants of CD40 and CD40L genes interact to promoteantibiotic-induced cutaneous allergic reactions // Clin. Exp. Allergy. - 2009; 39 (12): 1852-6.
Gueant1 J., Gueant-Rodriguez R. et al. Pharmacogenetic Determinants of Immediate and Delayed Reactions of Drug Hypersensitivity // Cur. Pharm. Des. -2008; 14 (27): 2770-7.

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