Zonulin as a marker of intestinal permeability in patients with acne associated with celiac disease

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详细

The intestinal barrier plays an important role in maintaining gut and whole body immune homeostasis. The role of the gastrointestinal microbiota is significant in maintaining intestinal tightness as the latter affects the intestinal barrier. Shifting the balance of the gut microbiota composition towards opportunistic microorganisms is known to lead to increased secretion of the recently discovered protein zonulin. The level of zonulin in patients with various diseases makes it possible to judge the change in intestinal wall permeability during pathological processes or different types of therapy. The present study examined for the first time the effect of a gluten-free diet on the course of acne in patients with and without celiac disease. The given study was the first to investigate the effect of a gluten-free diet on the course of acne in patients with and without celiac disease.

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作者简介

S. Ledentsova

Consultative and Diagnostic Center, Saint Petersburg State Pediatric Medical University Ministry of Health of Russia

Email: seliverstov-pv@yandex.ru
ORCID iD: 0000-0001-9897-5989
俄罗斯联邦, Saint Petersburg

N. Gulyaev

A.A. Vishnevsky Central Military Clinical Hospital. Ministry of Defense of Russia

Email: seliverstov-pv@yandex.ru
ORCID iD: 0000-0002-7578-8715

Doctor of Medical Sciences

俄罗斯联邦, Krasnogorsk

S. Klyuchereva

I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia

Email: seliverstov-pv@yandex.ru

Doctor of Medical Sciences, Professor

俄罗斯联邦, Saint Petersburg

L. Oreshko

I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia

Email: seliverstov-pv@yandex.ru
ORCID iD: 0000-0002-2726-9996

Doctor of Medical Sciences, Professor

俄罗斯联邦, Saint Petersburg

P. Seliverstov

S.M. Kirov Military Medical Academy, Ministry of Defense of Russia

编辑信件的主要联系方式.
Email: seliverstov-pv@yandex.ru
ORCID iD: 0000-0001-5623-4226

Candidate of Medical Sciences, Associate Professor

俄罗斯联邦, Saint Petersburg

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2. Fig. 1. The gut microbiota in Group 1 at baseline and after 12 months of adherence to a gluten-free diet (GFD)

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3. Fig. 2. The gut microbiota in Group 2 at baseline and after 12 months of adherence to GFD

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4. Fig. 3. Comparative analysis of fecal zonulin concentrations in both groups adhering to GFD for 12 months

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5. Fig. 4. Comparative analysis of acne dermatology index in both groups adhering to GFD for 12 months

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