Polymorphism of the APOE gene: prevalence of phenotypes in the population and an association with the development of Alzheimer's disease
- 作者: Volobuyev A.N.1, Romanchuk P.I.1, Romanchuk N.P.1, Krasnov S.V.1, Davydkin I.L.1
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隶属关系:
- Samara State Medical University
- 期: 卷 34, 编号 6 (2023)
- 页面: 73-75
- 栏目: From Practice
- URL: https://journals.eco-vector.com/0236-3054/article/view/529661
- DOI: https://doi.org/10.29296/25877305-2023-06-15
- ID: 529661
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详细
Based on the Hardy–Weinberg theory and statistical studies, the authors analyzedthe prevalence of different APOE gene alleles in the populationto reveal the relatioship between the alelle structure of a phenotype and the risk for Alzheimer's disease. Based on the concept of dominant and recessive zygote structures of allelic polymorphism of the APOE gene, it was shown that there must be three phenotypes that determine the risk for Alzheimer's disease. The prevalence of these phenotypes in the human population was studied.
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作者简介
A. Volobuyev
Samara State Medical University
编辑信件的主要联系方式.
Email: volobuev47@yandex.ru
Biol.D., Professor
俄罗斯联邦, SamaraP. Romanchuk
Samara State Medical University
Email: volobuev47@yandex.ru
Candidate of Medical Sciences
俄罗斯联邦, SamaraN. Romanchuk
Samara State Medical University
Email: volobuev47@yandex.ru
Candidate of Medical Sciences, Associate Professor
俄罗斯联邦, SamaraS. Krasnov
Samara State Medical University
Email: volobuev47@yandex.ru
Biol.D, Professor
俄罗斯联邦, SamaraI. Davydkin
Samara State Medical University
Email: volobuev47@yandex.ru
Doctor of Medical Sciences, Professor
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