Polymorphism of the APOE gene: prevalence of phenotypes in the population and an association with the development of Alzheimer's disease
- Authors: Volobuyev A.N.1, Romanchuk P.I.1, Romanchuk N.P.1, Krasnov S.V.1, Davydkin I.L.1
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Affiliations:
- Samara State Medical University
- Issue: Vol 34, No 6 (2023)
- Pages: 73-75
- Section: From Practice
- URL: https://journals.eco-vector.com/0236-3054/article/view/529661
- DOI: https://doi.org/10.29296/25877305-2023-06-15
- ID: 529661
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Abstract
Based on the Hardy–Weinberg theory and statistical studies, the authors analyzedthe prevalence of different APOE gene alleles in the populationto reveal the relatioship between the alelle structure of a phenotype and the risk for Alzheimer's disease. Based on the concept of dominant and recessive zygote structures of allelic polymorphism of the APOE gene, it was shown that there must be three phenotypes that determine the risk for Alzheimer's disease. The prevalence of these phenotypes in the human population was studied.
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About the authors
A. N. Volobuyev
Samara State Medical University
Author for correspondence.
Email: volobuev47@yandex.ru
Biol.D., Professor
Russian Federation, SamaraP. I. Romanchuk
Samara State Medical University
Email: volobuev47@yandex.ru
Candidate of Medical Sciences
Russian Federation, SamaraN. P. Romanchuk
Samara State Medical University
Email: volobuev47@yandex.ru
Candidate of Medical Sciences, Associate Professor
Russian Federation, SamaraS. V. Krasnov
Samara State Medical University
Email: volobuev47@yandex.ru
Biol.D, Professor
Russian Federation, SamaraI. L. Davydkin
Samara State Medical University
Email: volobuev47@yandex.ru
Doctor of Medical Sciences, Professor
Russian Federation, SamaraReferences
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