A comparative study of lappaconitine hydrobromide extended release and propafenone in patients with paroxysmal atrial fibrillation
- 作者: Revishvili A.1, Golitsyn S.2, Aksentiev S.3, Amiraslanov A.1, Artyukhina E.1, Duplyakov D.4, Zubov E.5, Isaeva E.6, Loginova A.2, Malkina T.2, Miloserdov G.3, Rivin A.7, Teplykh S.8, Tsygankova I.3, Shvarts Y.9, Yuricheva Y.2, Kanorsky S.10, Sokolov S.2
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隶属关系:
- National Medical Research Center of Surgery named after A.Vishnevsky, Ministry of Health of Russia
- National Medical Research Centre of cardiology named after Academician E.I. Chazov, Ministry of Health of Russia
- Regional Clinical Hospital
- V.P. Polyakov Samara Region Clinical Cardiological Dispensary
- LLC «Professor's Clinic»
- Interregional Clinical Diagnostic Center
- AntMed LLC
- LLC «Center for Professional Medicine»
- Saratov State Medical University named after V.I. Razumovsky
- Kuban State Medical University, Ministry of Health of Russia
- 期: 卷 35, 编号 1 (2024)
- 页面: 20-26
- 栏目: Pharmacology
- URL: https://journals.eco-vector.com/0236-3054/article/view/626876
- DOI: https://doi.org/10.29296/25877305-2024-01-04
- ID: 626876
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详细
A new dosage form of lappaconitine hydrobromide has been created – the long-acting drug Allaforte®, which has fewer side effects compared to the traditional dosage form (Allapinin®).
Objective. To evaluate the effectiveness, safety and tolerability of Allaforte® therapy in comparison with the drug Rytmonorm® in patients with paroxysmal atrial fibrillation (AF).
Material and methods. Patients who met the inclusion criteria and those who did not meet the non-inclusion criteria were randomized into 2 groups: 1st (n=50) – patients received Allaforte® 25 mg 3 times a day with an increase in dose to 50 mg 2 times a day when detected attack of AF; 2nd (n=50) – patients received Rytmonorm® 150 mg 3 times a day with an increase in dose to 300 mg 2 times a day if an attack of AF was detected.
Results. The average time from the first dose of the drug to the development of AF paroxysm in the 1st group (Allaforte®) was 98.877±6.022 days, in the 2nd group (Rytmonorm®) – 98.808±5.876 days, the average time from the first dose of the drug to the completion of the study – 105.740±5.032 and 103.732±5.353 days, respectively. The drugs Allaforte® and Rytmonorm® equally improved the quality of life of patients. A comparative analysis in groups according to the severity of adverse events and their cause-and-effect relationship with the drug did not show significant differences.
Conclusion. The study drugs showed comparable effectiveness in preventing attacks of AF with similar safety and tolerability.
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作者简介
A. Revishvili
National Medical Research Center of Surgery named after A.Vishnevsky, Ministry of Health of Russia
编辑信件的主要联系方式.
Email: kanorskysg@mail.ru
Professor, Academician of the Russian Academy of Sciences, MD
俄罗斯联邦, MoscowS. Golitsyn
National Medical Research Centre of cardiology named after Academician E.I. Chazov, Ministry of Health of Russia
Email: kanorskysg@mail.ru
Professor, MD
俄罗斯联邦, MoscowS. Aksentiev
Regional Clinical Hospital
Email: kanorskysg@mail.ru
Candidate of Medical Sciences
俄罗斯联邦, RyazanA. Amiraslanov
National Medical Research Center of Surgery named after A.Vishnevsky, Ministry of Health of Russia
Email: kanorskysg@mail.ru
俄罗斯联邦, Moscow
E. Artyukhina
National Medical Research Center of Surgery named after A.Vishnevsky, Ministry of Health of Russia
Email: kanorskysg@mail.ru
MD
俄罗斯联邦, MoscowD. Duplyakov
V.P. Polyakov Samara Region Clinical Cardiological Dispensary
Email: kanorskysg@mail.ru
Professor, MD
俄罗斯联邦E. Zubov
LLC «Professor's Clinic»
Email: kanorskysg@mail.ru
Candidate of Medical Sciences
俄罗斯联邦, PermE. Isaeva
Interregional Clinical Diagnostic Center
Email: kanorskysg@mail.ru
Candidate of Medical Sciences
俄罗斯联邦, KazanA. Loginova
National Medical Research Centre of cardiology named after Academician E.I. Chazov, Ministry of Health of Russia
Email: kanorskysg@mail.ru
俄罗斯联邦, Moscow
T. Malkina
National Medical Research Centre of cardiology named after Academician E.I. Chazov, Ministry of Health of Russia
Email: kanorskysg@mail.ru
Candidate of Medical Sciences
俄罗斯联邦, MoscowG. Miloserdov
Regional Clinical Hospital
Email: kanorskysg@mail.ru
俄罗斯联邦, Ryazan
A. Rivin
AntMed LLC
Email: kanorskysg@mail.ru
俄罗斯联邦, Saint Petersburg
S. Teplykh
LLC «Center for Professional Medicine»
Email: kanorskysg@mail.ru
俄罗斯联邦, Perm
I. Tsygankova
Regional Clinical Hospital
Email: kanorskysg@mail.ru
俄罗斯联邦, Ryazan
Yu. Shvarts
Saratov State Medical University named after V.I. Razumovsky
Email: kanorskysg@mail.ru
Professor, MD
俄罗斯联邦Yu. Yuricheva
National Medical Research Centre of cardiology named after Academician E.I. Chazov, Ministry of Health of Russia
Email: kanorskysg@mail.ru
Candidate of Medical Sciences
俄罗斯联邦, MoscowS. Kanorsky
Kuban State Medical University, Ministry of Health of Russia
Email: kanorskysg@mail.ru
Professor, MD
俄罗斯联邦, KrasnodarS. Sokolov
National Medical Research Centre of cardiology named after Academician E.I. Chazov, Ministry of Health of Russia
Email: kanorskysg@mail.ru
Candidate of Medical Sciences
俄罗斯联邦, Moscow参考
- Dong X.J., Wang B.B., Hou F.F. et al. Global burden of atrial fibrillation/atrial flutter and its attributable risk factors from 1990 to 2019. Europace. 2023; 25 (3): 793–803. doi: 10.1093/europace/euac237
- Jahangir A., Lee V., Friedman P.A. et al. Long-term progression and outcomes with aging in patients with lone atrial fibrillation: a 30-year follow-up study. Circulation. 2007; 115 (24): 3050–6. doi: 10.1161/CIRCULATIONAHA.106.644484
- Kirchhof P., Camm A.J., Goette A. et al. Early Rhythm-Control Therapy in Patients with Atrial Fibrillation. N Engl J Med. 2020; 383 (14): 1305–16. doi: 10.1056/NEJMoa2019422
- Schnabel R.B., Marinelli E.A., Arbelo E. et al. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference. Europace. 2023; 25 (1): 6–27. doi: 10.1093/europace/euac062
- Saljic A., Heijman J., Dobrev D. Recent Advances in Antiarrhythmic Drug Therapy. Drugs. 2023; 83 (13): 1147–60. doi: 10.1007/s40265-023-01923-3
- Hindricks G., Potpara T., Dagres N. et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J. 2021; 42 (5): 373–498. doi: 10.1093/eurheartj/ehaa612
- Tran Q.T., Baek I.H., Han N.Y. et al. The Effect of CYP2D6 Phenotypes on the Pharmacokinetics of Propafenone: A Systematic Review and Meta-Analysis. Pharmaceutics. 2022; 14 (7): 1446. doi: 10.3390/pharmaceutics14071446
- Соколов С.Ф., Беляева М.М., Бакалов С.А. и др. Сравнительная эффективность и безопасность двух лекарственных форм лаппаконитина гидробромида при желудочковой экстрасистолии у больных без органической патологии сердца. Кардиология. 2017; 57 (4): 91–5 [Sokolov S.F., Belyaeva M.M., Bakalov S.A. et al. Comparative efficacy and safety of two medicine forms of lappaconitin hydrobromide in patients with ventricular extrasystole without organic pathology of the heart. Kardiologiia. 2017; 57 (4): 91–5 (in Russ.)]. doi: 10.18565/cardio.2017.4.5-11
- Wynn G.J., Todd D.M., Webber M. et al. The European Heart Rhythm Association symptom classification for atrial fibrillation: validation and improvement through a simple modification. Europace. 2014; 16 (7): 965–72. doi: 10.1093/europace/eut395
- Rillig A., Magnussen C., Ozga A.K. et al. Early Rhythm Control Therapy in Patients With Atrial Fibrillation and Heart Failure. Circulation. 2021; 144 (11): 845–58. doi: 10.1161/CIRCULATIONAHA.121.056323
- Chung S.C., Lai A., Lip G.Y.H. et al. Impact of anti-arrhythmic drugs and catheter ablation on the survival of patients with atrial fibrillation: a population study based on 199 433 new-onset atrial fibrillation patients in the UK. Europace. 2023; 25 (2): 351–9. doi: 10.1093/europace/euac155
- Echt D.S., Liebson P.R., Mitchell L.B. et al. Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial. N Engl J Med. 1991; 324 (12): 781–8. doi: 10.1056/NEJM199103213241201
- Cardiac Arrhythmia Suppression Trial II Investigators. Effect of the antiarrhythmic agent moricizine on survival after myocardial infarction. N Engl J Med. 1992; 327 (4): 227–33. doi: 10.1056/NEJM199207233270403
- Burnham T.S., May H.T., Bair T.L. et al. Long-term outcomes in patients treated with flecainide for atrial fibrillation with stable coronary artery disease. Am Heart J. 2022; 243: 127–39. doi: 10.1016/j.ahj.2021.08.013
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