Hair aging as an urgent problem of modern medicine
- Authors: Ledentsova S.S.1, Seliverstov P.V.2, Shenderovich E.M.3
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Affiliations:
- Consultative and Diagnostic Center of Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia
- S.M. Kirov Military Medical Academy, Ministry of Defense of Russia
- N.F. Gamaleya Research Institute of Epidemiology and Microbiology, Ministry of Health of Russia
- Issue: Vol 36, No 7 (2025)
- Pages: 17-22
- Section: Problem
- URL: https://journals.eco-vector.com/0236-3054/article/view/689848
- DOI: https://doi.org/10.29296/25877305-2025-07-03
- ID: 689848
Cite item
Abstract
Hair, like the skin and the human body as a whole, is subject to aging processes, which can be roughly divided into 2 aspects: aging of the hair shaft and aging of the hair follicle. There are currently no drugs for the targeted treatment of graying hair with proven effectiveness, and their development is the subject of scientific research. As for the treatment of age-related hair changes, it includes specific pharmacological therapies for hair loss, such as topical application of minoxidil and inhibition of 5-alpha reductase, as well as correction of age-related general health problems affecting the condition of the hair, such as: diseases of the gastrointestinal tract with impaired absorption of nutrients necessary for hair fiber disorders, endocrine diseases, psychological disorders related to substance abuse, and polymorbidity. In addition to using external remedies, to prevent alopecia, strengthen the hair follicle and hair structure, it is of great importance to supply the body with nutrients that ensure the health of the skin and its appendages. There is every reason to consider modern Russian developments Osteomed and Osteo-Vit D₃ as rich sources of such substances, which is the subject of our article.
Keywords
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About the authors
S. S. Ledentsova
Consultative and Diagnostic Center of Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia
Author for correspondence.
Email: seliverstov-pv@yandex.ru
ORCID iD: 0000-0001-9897-5989
SPIN-code: 3972-1462
Candidate of Medical Sciences
Russian Federation, Saint Petersburg
P. V. Seliverstov
S.M. Kirov Military Medical Academy, Ministry of Defense of Russia
Email: seliverstov-pv@yandex.ru
ORCID iD: 0000-0001-5623-4226
SPIN-code: 6166-7005
Associate Professor, Candidate of Medical Sciences
Russian Federation, Saint PetersburgE. M. Shenderovich
N.F. Gamaleya Research Institute of Epidemiology and Microbiology, Ministry of Health of Russia
Email: seliverstov-pv@yandex.ru
ORCID iD: 0009-0003-3382-1411
Russian Federation, Moscow
References
- Trueb R. M. Aging of hair. J Cosmet Dermatol. 2005; 4: 60–72. doi: 10.1111/j.1473-2165.2005.40203.x
- Li L., Mignone J., Yang M. et al. Nestin expression in hair follicle sheath progenitor cells. Proc Natl Acad Sci USA. 2003; 100: 9958–61. doi: 10.1073/pnas.1733025100
- Trüeb R.M., Tobin D.J. (Eds.) Aging Hair. Springer, 2010; р. 270.
- Pinkus H. Alopecia. Clinicopathologic correlations. Int J Dermatol. 1980; 19 (5): 245–53. doi: 10.1111/j.1365-4362.1980.tb00318.x
- Ebling F.J. Age changes in cutaneous appendages. J Appl Cosmetol. 1985; 3: 243–50.
- Kligman A.M. The comparative histopathology of male-pattern baldness and senescent baldness. Clin Dermatol. 1988; 6 (4): 108–18. doi: 10.1016/0738-081x(88)90074-0
- Courtois M., Loussouarn G., Hourseau C. et al. Ageing and hair cycles. Br J Dermatol. 1995; 132 (1): 86–93. doi: 10.1111/j.1365-2133.1995.tb08630.x
- Keogh E.V., Walsh R.J. Rate of greying of human hair. Nature. 1965; 207 (4999): 877–8. doi: 10.1038/207877a0
- Panhard S., Lozano I., Loussouarn G. Greying of the human hair: a worldwide survey, revisiting the '500 rule of thumb. Br J Dermatol. 2012; 167 (4): 865–73. doi: 10.1111/j.1365-2133.2012.11095.x
- Pandhi D., Khanna D. Premature graying of hair. Indian J Dermatol Venereol Leprol. 2013; 79 (5): 641–53. doi: 10.4103/0378-6323.116733
- Tobin D.J., Paus R. Graying: gerontobiology of the hair follicle pigmentary unit. Exp Gerontol. 2001; 36 (1): 29–54. doi: 10.1016/s0531-5565(00)00210-2
- Orr-Walker B.J., Evans M.C., Ames R.W. et al. Premature hair graying and bone mineral density. J Clin Endocrinol Metab. 1997; 82 (11): 3580–3. doi: 10.1210/jcem.82.11.4338
- Rosen C.J., Holick M.F., Millard P.S. Premature graying of hair is a risk marker for osteopenia. J Clin Endocrinol Metab. 1994; 79 (3): 854–7. doi: 10.1210/jcem.79.3.8077373
- Bhutani L.K., Minocha Y.K., Dhir G.G. et al. Repigmentation of hair following photosensitive dermatitis. Dermatologica. 1978; 156 (2): 101–4. doi: 10.1159/000250904
- Shaffrali F.C., McDonagh A.J., Messenger A.G. Hair darkening in porphyria cutanea tarda. Br J Dermatol. 2002; 146 (2): 325–9. doi: 10.1046/j.1365-2133.2002.04591.x
- Dummer R. Clinical picture: hair repigmentation in lentigo maligna. Lancet. 2001; 357 (9256): 598. doi: 10.1016/s0140-6736(00)04059-9
- Dinh H.V., Sinclair R., Martinick J. Long-term hair repigmentation following a hair transplant for frontal scarring alopecia. Australas J Dermatol. 2007; 48 (4): 236–8. doi: 10.1111/j.1440-0960.2007.00394.x
- Inzinger M., Massone C., Arzberger E. et al. Hair repigmentation in melanoma. Lancet. 2013; 382 (9899): 1224. doi: 10.1016/S0140-6736(13)61604-9
- Fernandez-Flores A., Manjon J.A. Repigmentation of gray hair in lesions of annular elastolytic giant cell granuloma. Cutis. 2015; 96 (1): E19-22.
- Qiu W., Chuong C.M., Lei M. Regulation of melanocyte stem cells in the pigmentation of skin and its appendages: biological patterning and therapeutic potentials. Exp Dermatol. 2019; 28 (4): 395–405. doi: 10.1111/exd.13856
- Cheng Y.P., Chen H.J., Chiu H.C. Erlotinib-induced hair repigmentation. Int J Dermatol. 2014; 53 (1): e55–7. doi: 10.1111/j.1365-4632.2011.05422.x
- Tintle S.J., Dabade T.S., Kalish R.A. et al. Repigmentation of hair following adalimumab therapy. Dermatol Online J. 2015; 21 (6): 13030/qt6fn0t1xz.
- Sebaratnam D.F., Rodriguez Bandera A.I., Lowe P.M. Hair Repigmentation with anti-PD-1 and anti-PD-L1 immunotherapy: a novel hypothesis. JAMA Dermatol. 2018; 154 (1): 112–3. doi: 10.1001/jamadermatol.2017.4420
- Rivera N., Boada A., Ferrándiz C. Hair Repigmentation with anti-PD-1 and anti-PD-L1 immunotherapy: a novel hypothesis-reply. JAMA Dermatol. 2018; 154 (1): 113–4. doi: 10.1001/jamadermatol.2017.4419
- Manson G., Marabelle A., Houot R. Hair Repigmentation with anti-PD-1 and anti-PD-L1 immunotherapy: a novel hypothesis. JAMA Dermatol. 2018; 154 (1): 113. doi: 10.1001/jamadermatol.2017.4421
- Penzi L.R., Manatis-Lornell A., Saavedra A. et al. Hair repigmentation associated with the use of brentuximab. JAAD Case Rep. 2017; 3 (6): 563–5. doi: 10.1016/j.jdcr.2017.09.027
- Correa-Selm L.M., Grichnik J.M. PD1 inhibitors and hair repigmentation: a desirable new side effect. Dermatol Ther. 2018; 31 (1): e12560. doi: 10.1111/dth.12560
- Rivera N., Boada A., Bielsa M.I. et al. Hair Repigmentation during immunotherapy treatment with an anti-programmed cell death 1 and antiprogrammed cell death ligand 1 agent for lung cancer. JAMA Dermatol. 2017; 153 (11): 1162–5. doi: 10.1001/jamadermatol.2017.2106
- Birch M.P., Messenger J.F., Messenger A.G. Hair density, hair diameter and the prevalence of female pattern hair loss. Br J Dermatol. 2001; 144 (2): 297–304. doi: 10.1046/j.1365-2133.2001.04018.x
- Nagase S., Kajiura Y., Mamada A. et al. Changes in structure and geometric properties of human hair by aging. J Cosmet Sci. 2009; 60 (6): 637–48.
- Nagase S., Tsuchiya M., Matsui T. et al. Characterization of curved hair of Japanese women with reference to internal structures and amino acid composition. J Cosmet Sci. 2008; 59 (4): 317–32.
- Price V.H., Sawaya M.E., Headington J.T. Histology and hormonal activity in senescent thinning in men. Presentation at SID, Annual Meeting; Washington, DC. 2001.
- Trüeb R.M. Minoxidil for endocrine therapy-induced alopecia in women with breast cancer-Saint Agatha's blessing? JAMA Dermatol. 2018; 154 (6): 656–8. doi: 10.1001/jamadermatol.2018.0453
- Струков В.И., Катюшина Ю.Г., Еремина Н.В. и др. Остеомед – эффективный регулятор минеральной плотности костей и закрытия полостных образований при лечении пресенильного и сенильного остеопороза. Поликлиника. 2013; 1: 90–1 [Strukov V.I., Katyushina Yu.G., Eremina N.V., Filippova O.V. Osteomed is an effective regulator of bone mineral density and closure of cavity formations in the treatment of presenile and senile osteoporosis. Poliklinika. 2013; 1: 90–1 (in Russ.)].
- Комаров В.Т. Сравнительная характеристика комплексного лечения ревматоидного полиартрита с вторичным системным остеопорозом препаратами Остеомед и Остео-Вит D₃. Врач. 2023; 34 (6): 82–5 [Komarov V.T. Comparative characteristics of the complex treatment of rheumatoid polyarthritis with secondary systemic osteoporosis with Osteomed and Osteo-Vit D₃ drugs. Vrach. 2023; 34 (6): 82–5 (in Russ.)]. doi: 10.29296/25877305-2023-06-17
- Купцова Т., Кислов А., Струков В. и др. Остео-Вит D₃ в лечении детей с повторными переломами костей при остеопорозе. Врач. 2016; 1: 46–7 [Kupczova T., Kislov A., Strukov V. et al. Osteo-Vit D₃ in the treatment of children with repeated bone fractures in osteoporosis. Vrach. 2016; 1: 46–7 (in Russ.)].
- Митрофанов Д.В., Будникова Н.В., Бурмистрова Л.А. Гормоны трутневого расплода медоносных пчел разного возраста. Пчеловодство. 2015; 7: 58–9 [Mitrofanov D.V., Budnikova N.V., Burmistrova L.A. Hormones of the drone brood of honey bees of different ages. Pchelovodstvo. 2015; 7: 58–9 (in Russ.)].
- Бурмистрова Л.А. Физико-химический анализ и биохимическая оценка биологической активности трутневого расплода. Дисс. … канд. биол. наук. Рязань, 1999 [Burmistrova L.A. Physical and chemical analysis and biochemical assessment of the biological activity of drone brood. Diss. … cand. biol. nauk. Ryazan, 1999 (in Russ.)].
- Митрофанов Д.В., Будникова Н.В., Брандорф А.З. Применение трутневого расплода в рациональном питании и апитерапии. Аграрная наука Евро-Северо-Востока. 2021; 22 (2): 188–203 [Mitrofanov D.V., Budnikova N.V., Brandorf A.Z. Application of drone brood in rational nutrition and apitherapy. Agricultural Science Euro-North-East. 2021; 22 (2): 188–203 (in Russ.)]. doi: 10.30766/2072-9081.2021.22.2.188-203
- Минасов Т.Б., Алакаева Д.Р., Фаткуллина Л.З. и др. Уровень женских половых гормонов и их взаимосвязь с витамином D у пациентов разных возрастных групп. Врач скорой помощи. 2020; 11: 71–8 [Minasov T.B., Alakaeva D.R., Fatkullina L.Z. et al. The level of female hormones and their relationship with vitamin D in patients of different age groups. Ambulance Doctor. 2020; 11: 71–8 (in Russ.)]. doi: 10.33920/med-02-2011-05
- Литвин Ф.Б., Брук Т.М., Терехов П.А. и др. Влияние биологически активной добавки на основе гомогената трутневых личинок на микроциркуляцию и обмен веществ у лыжников-гонщиков. Спортивная медицина: наука и практика. 2018; 8 (3): 88–95 [Litvin F.B., Bruk T.M., Prokhoda I.A. et al. Effect of biologically active additives based on the homogenate of drone larvae on microcirculation and metabolism in Nordic skiers. Sports medicine: research and practice. 2018; 8 (3): 88–95 (in Russ.)]. doi: 10.17238/ISSN2223-2524.2018.3.88
- Мещеряков Ю.И. Применение препаратов из личинок трутней и подмора пчел при пироплазмидозах животных. В сб.: Современные проблемы ветеринарной практики в АПК: мат-лы II Всеросс. научно-практ. интернет-конф. Практ. специалистов. Ставрополь: АГРУС, 2016; с. 272–4 [Meshcheryakov Yu.I. The use of preparations from drone larvae and bee podora in case of pyroplasmidosis of animals. In the collection: Modern problems of veterinary practice in agriculture: proceedings of the II All-Russian scientific and practical Internet conference of practitioners. Stavropol: AGRUS, 2016; рр. 272–4 (in Russ.)].
- Ефанова Н.В., Осина Л.М., Баталова С.В. Влияние трутневого гомогената на элементный и метаболический статус собак. Инновации и продовольственная безопасность. 2019; 2 (24): 58–63 [Efanova N.V., Osina L.M., Batalova S.V. Influence of molding homogenates on element and metabolic status of dogs. Innovations and Food Safety. 2019; 2: 58–63 (in Russ.)]. doi: 10.31677/2311-0651-2019-24-2-58-63
- Громова О.А., Торшин И.Ю., Пронин А.В. и др. Значение кальция для здоровья кожи, волос и ногтей и вопросы рациональной коррекции его потребления. РМЖ. Медицинское обозрение. 2014; 22 (24): 1796–9 [Gromova O.A., Torshin I.Y., Pronin A.V. et al. Importance of calcium for skin, hair and nails health and issues of rational correction of its consumption. RMJ. Medical Review. 2014; 22 (24): 1796–9 (in Russ.)].
- Поворознюк В.В., Снежицкий В.А., Янковская Л.В. и др. Значение витамина D в патогенезе сердечно-сосудистых заболеваний. Журнал Гродненского государственного медицинского университета. 2015; 2: 6–14 [Povorozniuk V.V., Snezhitskii V.A., Iankovskaia L.V. et al. The importance of vitamin D in the pathogenesis of cardiovascular diseases. Journal of the Grodno State Medical University. 2015; 2: 6–14 (in Russ.)].
- Almohanna H.M., Ahmed A.A., Tsatalis J.P., et al. The Role of Vitamins and Minerals in Hair Loss: A Review. Dermatol Ther (Heidelb). 2019; 9 (1): 51–70. doi: 10.1007/s13555-018-0278-6
- Ernst und Soltz-Szots. Neue Methode zur zbehandlung des seborrhoischen Haarausfallemit Vitamin B6. Med Kosmetik. 1950; 7: 201–9.
- Гаджигороева А.Г. Системная терапия диффузной алопеции и структурного повреждения волос. Вестник эстетической медицины. 2008; 7 (1): 1–8 [Gadzhigoroeva A.G. Systemic therapy of diffuse alopecia and structural hair damage. Vestnik esteticheskoi meditsiny. 2008; 7 (1): 1–8 (in Russ.)].
- Митрофанов Д.В., Будникова Н.В., Есенкина С.Н. и др. Антиоксидантные соединения в гомогенате трутневого расплода разного возраста. Сборник научных трудов КНЦЗВ. 2021; 10 (1): 273–6 [Mitrofanov D.V., Budnikova N.V., Esenkina S.N., Repeva L.A. Antioxidant compounds in the homogenate of drone brood of different ages. Sbornik nauchnykh trudov KNTsZV. 2021; 10 (1): 273–6 (in Russ.)]. doi: 10.48612/7z9a-kgmt-dex6
- Джоунс О., Струков В., Кислов А. и др. Коморбидный остеопороз: проблемы и новые возможности терапии (Ч. 1). Врач. 2017; 10: 23–6, 11: 25–8 [O. Jones, V. Strukov,A. Kislov et al. Comorbid osteoporosis: challenges and new diagnostic opportunities (Part 1). Vrach. 2017; 10: 23–6 (in Russ.)].
- Трифонов В., Елистратов Д. Рекомендации по лечению остеопороза в условиях коморбидности и полипрагмазии с помощью препарата «Остемед Форте» и фитопрепаратов. Врач. 2018; 5: 87–8 [Trifonov V., Elistratov D. Recommendations for the treatment of osteoporosis in conditions of comorbidity and polypragmasia using the drug "Ostemed Forte" and phytopreparations. Vrach. 2018; 5: 87–8 (in Russ.)].
- Струков В.И., Сергеева-Кондраченко М.Ю., Виноградова О.П. и др. Коморбидный пациент с остеопорозом на приеме у врача. Какие факторы необходимо учитывать в подборе терапии. Медицинский алфавит. 2023; 18: 34–8 [Strukov V.I., Sergeeva-Kondrachenko M.Yu., Vinogradova O.P. et al. Comorbid patient with osteoporosis at doctor's appointment. What factors should be considered in selection of therapy. Medical alphabet. 2023; 18: 34–8 (in Russ.)]. doi: 10.33667/2078-5631-2023-18-34-38
- Дедов Д.В., Иванов А.Г., Михайлова Е.А. и др. Профилактика дефицита кальция и витамина D при остеопорозе: возможность применения комбинированных препаратов Остеомед, Остеомед Форте, Остео-Вит-D₃. Врач. 2023; 34 (3): 83–8 [Dedov D.V., Ivanov A.G., Mikhailova E.A. et al. Prevention of calcium and vitamin D deficiency in osteoporosis: the possibility of using combination drugs Osteomed, Osteomed Forte, Osteo-Vit-D₃. Vrach. 2023; 34 (3): 83–8 (in Russ.)]. doi: 10.29296/25877305-2023-03-18
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