Changes in progesterone levels in smoking women with impaired bronchial patency during gestation

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详细

The use of tobacco products for a long time leads not only to a violation of bronchial dysfunction, but also to a change in the hormonal background in women of fertile age. In a prospective randomized trial of patients attending a prenatal pregnancy clinic, statistically significant changes in progesterone were revealed depending on smoking in different trimesters of gestation, with the maximum sensitivity of the model (p ≤ 0.05) detected in the third trimester of gestation.

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作者简介

A. Dzyubailo

Samara State Medical University, Ministry of Health of Russia

编辑信件的主要联系方式.
Email: adzyubajlo@yandex.ru
ORCID iD: 0000-0001-6908-4829
SPIN 代码: 8254-7750

Associate Professor, Candidate of Medical Sciences

俄罗斯联邦, Samara

参考

  1. Tse H.N., Tseng C.Z. Update on the pathological processes, molecular biology, and clinical utility of N-acetylcysteine in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2014; 9: 825–36. doi: 10.2147/COPD.S51057
  2. Barnes P.J. Cellular and molecular mechanisms of chronic obstructive pulmonary disease. Clin Chest Med. 2014; 35 (1): 71–86. doi: 10.1016/j.ccm.2013.10.004
  3. Barnes P.J. Cellular and molecular mechanisms of asthma and COPD. Clin Sci (Lond). 2017; 131 (13): 1541–58. doi: 10.1042/CS20160487
  4. Barnes P.J. Oxidative stress-based therapeutics in COPD. Redox Biol. 2020; 33: 101544. doi: 10.1016/j.redox.2020.101544
  5. Bohr V.A., Stevnsner T., de Souza-Pinto N.C. Mitochondrial DNA repair of oxidative damage in mammalian cells. Gene. 2002; 286 (1): 127–34. doi: 10.1016/s0378-1119(01)00813-7
  6. Bohr V.A. Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells. Free Radic Biol Med. 2002; 32 (9): 804–12. doi: 10.1016/s0891-5849(02)00787-6
  7. Barnes P.J. Transcription factors in airway diseases. Lab Invest. 2006; 86 (9): 867–72. doi: 10.1038/labinvest.3700456
  8. Wu J.P., Wu Q., Sun X. et al. Corticosteroid resistance in chronic obstructive pulmonary disease: new uses of theophylline. Chin Med J (Engl). 2013; 126 (5): 965–70. doi: 10.3760/cma.j.issn.0366-6999.20121391
  9. Afonso V., Champy R., Mitrovic D. et al. Reactive oxygen species and superoxide dismutases: role in joint diseases. Joint Bone Spine. 2007; 74 (4): 324–9. doi: 10.1016/j.jbspin.2007.02.002
  10. Berman S.B., Pineda F.J., Hardwick J.M. Mitochondrial fission and fusion dynamics: the long and short of it. Cell Death Differ. 2008; 15 (7): 1147–52. doi: 10.1038/cdd.2008.57
  11. Jendrach M., Pohl S., Voth M. et al. Morpho-dynamic changes of mitochondria during ageing of human endothelial cells. Mech Ageing Dev. 2005; 126 (6–7): 813–21. doi: 10.1016/j.mad.2005.03.002
  12. Saaresranta T., Aittokallio T., Utriainen K. et al. Medroxyprogesterone improves nocturnal breathing in postmenopausal women with chronic obstructive pulmonary disease. Respir Res. 2005; 6 (1): 28. doi: 10.1186/1465-9921-6-28
  13. Wagenaar M., Vos P.J., Heijdra Y.F. et al. Combined treatment with acetazolamide and medroxyprogesterone in chronic obstructive pulmonary disease patients. Eur Respir J. 2002; 20 (5): 1130–7. doi: 10.1183/09031936.02.00016402
  14. Robertson C.L., Puskar A., Hoffman G.E. et al. Physiologic progesterone reduces mitochondrial dysfunction and hippocampal cell loss after traumatic brain injury in female rats. Exp Neurol. 2006; 197 (1): 235–43. doi: 10.1016/j.expneurol.2005.09.014
  15. Gaignard P., Frechou M., Schumacher M. et al. Progesterone reduces brain mitochondrial dysfunction after transient focal ischemia in male and female mice. J Cereb Blood Flow Metab. 2016; 36 (3): 562–8. doi: 10.1177/0271678X15610338
  16. Cai J., Cao S., Chen J. et al. Progesterone alleviates acute brain injury via reducing apoptosis and oxidative stress in a rat experimental subarachnoid hemorrhage model. Neurosci Lett. 2015; 600: 238–43. doi: 10.1016/j.neulet.2015.06.023
  17. Qin Y., Chen Z., Han X. et al. Progesterone attenuates Abeta(25–35)-induced neuronal toxicity via JNK inactivation and progesterone receptor membrane component 1-dependent inhibition of mitochondrial apoptotic pathway. J Steroid Biochem Mol Biol. 2015; 154: 302–11. doi: 10.1016/j.jsbmb.2015.01.002
  18. Gonzalez Deniselle M.C., Carreras M.C., Garay L. et al. Progesterone prevents mitochondrial dysfunction in the spinal cord of wobbler mice. J Neurochem. 2012; 122 (1): 185–95. doi: 10.1111/j.1471-4159.2012.07753.x
  19. Feng Q., Crochet J.R., Dai Q. et al. Expression of a mitochondrial progesterone receptor (PR-M) in leiomyomata and association with increased mitochondrial membrane potential. J Clin Endocrinol Metab. 2014; 99 (3): E390–9. doi: 10.1210/jc.2013-2008
  20. Abohalaka R. Bronchial epithelial and airway smooth muscle cell interactions in health and disease. Heliyon. 2023; 9 (9): 19976. doi: 10.1016/j.heliyon.2023.e19976
  21. Esteves P., Blanc L., Celle A. et al. Crucial role of fatty acid oxidation in asthmatic bronchial smooth muscle remodelling. Eur Respir J. 2021; 58 (5): 2004252. doi: 10.1183/13993003.04252-2020

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