卷 28, 编号 3 (2017)

The paper discusses the possibilities of therapeutic use of L-carnitine (Elkar®) in cardiovascular, liver and kidney diseases, male infertility, Alzheimeґs disease, cachexia, and obesity, in sports medicine.

In conditions accompanied by an increase in the volume of circulating fluid (sodium-dependent hypertension, preeclampsia), there are elevated plasma concentrations of one of the key endogenous digitalis-like factors of marinobufagenin. Clinical trials investigate the efficacy of antibodies to digitalislike substances in the treatment of preeclampsia.

The paper analyzes the identified real prevalence rates of hypertension and coronary heart disease in working women and their risk factors related to the features of their profession, which form cardiovascular risks and reduce performance capability.

The paper considers the treatment of central spasticity and myofascial pain syndromes with oral muscle relaxants and another therapy. It presents a number of recommendations for the management of patients of this gpoup. The data available in the literature data on spasticity treatment with oral muscle relaxants are given.

Mild and moderate cognitive impairments (CIs) are observed in the early stages of cerebral diseases and widespread in clinical practice. Despite their nosological heterogeneity, there is a common neurochemical substrate of non-dementia CIs as neurotransmitter (dopaminergic, noradrenergic, other) deficiency in many cases. Although today there is no single approach to therapy for non-dementia CIs, the experience suggests the potential effectiveness of compensation for dopaminergic and noradrenergic deficiency. There are data on the use of the dopamine agonist and а-adrenoreceptor piribedil to treat mild and moderate CIs. This therapy was shown to significantly improve cognitive functions, primarily governing (planning and control) functions and memory. The significant efficiency of the treatment was determined even at the end of its second week.

In the structure of seasonal death rates in adults and children, there is a predominance of acute respiratory infections (ARI) of different etiologies, which occur with the involvement of the upper respiratory tract (URT), trachea, and bronchi and have a certain similarity in the development of pathogenesis and clinical symptoms. The paper gives the results of studying the clinical efficiency and safety of Oscillococcinum therapy for ARI with URT involvement in patients with comorbidities versus symptomatic therapy.

Changes in intracardiac hemodynamic parameters (from the latent diastolic dysfunction and adaptive remodeling of the left ventricle to the development of dysadaptive myocardial remodeling with signs of chronic heart failure) can be considered as a risk factor for cardiovascular events in rheumatic diseases.

The application of current bandages, such as ASEPTICORB-DT and ASEPTICORB-DC, substantially reduces the transition from the first phase of a wound process to the second one in patients with non-extensive purulent damages to the skin and subcutaneous tissue.

The paper analyzes the role of respiratory viral agents (influenza A and B viruses, adenoviruses, and respiratory syncytial virus) in the development of bronchiolitis obliterans.

Examination of 2 patient groups has shown that hypertensive patients, unlike healthy individuals with the balance of the mechanisms of blood flow regulation, had decreased vasomotor activity of microvessels and increased tone of the resistance component of the microvascular bed.

The most significant modifiable risk factors in hypertensive patients from rural areas have been proven to be smoking and alcohol (among males in particular); psychoemotional tension and stresses; malnutrition. Assessment of health and risk factors of hypertension necessitates the development of a program aimed at optimizing the prevention of the disease in this population