Pregnancy, labor, and postpartum in women after uterine surgery for undifferentiated connective tissue dysplasia


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Abstract

The authors studied the course of pregnancy, labor, postpartum, and neonates' status in women with undifferentiated connective tissue dysplasia (uCTD) and the morphological and immunohistochemical features of a uterine scar. The study included 95 patients aged 18 to 40 years who had a uterine scar following cesarean section. The clinical signs of a defective uterine scar were more frequently detectable in the uCTD group. The morphological substrate of this scar was progressive disorganization of connective tissue with inflammatory reactions and atrophic changes, with imbalance of collagen type IV, laminin, and a relative reduction in scar tissue vascular endothelial growth factor.

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