Impact of hyperhomocystinemia on the severity of hypertension in pregnant women and on perinatal outcomes


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Abstract

One hundred and four women in the third trimester of pregnancy, including 72 with preeclampsia (a study group) and 32 with physiological pregnancy (a control group), were examined. In preeclampsia, the plasma level of homocysteine was much higher than that in normal pregnancy. There was a direct correlation between the plasma level of homocysteine and the severity of preeclampsia. The concentration of homocysteine was higher than 5.5 μmol/E in all the pregnant women with severe preeclampsia and in 77.3% of those with moderate preeclampsia. There was a direct correlation between the plasma level of homocysteine and the value of blood pressure, proteinuria, the frequency of surgical preterm labor delivery and early neonatal complications.

About the authors

Lyudmila Evgen'evna Murashko

Email: ncagp@bk.ru

Z T Badoeva

F S Badoeva

L Z Fayzullin

L Ye Murashko

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Z T Badoyeva

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

F S Badoyeva

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

L Z Faizullin

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

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