Connective tissue disorganization in uterine scars and estrogen receptor-α gene polymorphism in patients with the undifferentiated forms of connective tissue dysplasia


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Abstract

In 90 women aged 18 to 40 years who had a post-cesarean section uterine scar, its morphological and immunohistochemical features were studied, by identifying the possible molecular genetic predictors of its consistency as estrogen receptor-α gene polymorphism. The morphological substrate of scar inconsistency in undifferentiated connective tissue dysplasia (uCTD) is the progressive connective tissue disorganization to fibrinoid necrosis, which is characterized by the impaired levels of laminin and collagen type IV; moreover, the cause of tissue disorganization is likely to be relative microcirculatory bed inconsistency. The post-cesarean section formation of an inconsistent uterine scar in uCTD is genetically determined, which determines a predisposition to connective tissue disorganization in the scar with the ESR1:-397 T > C (Pvull) and -351G > A (Xbal) gene polymorphisms.

About the authors

Gennadiy Tikhonovich Sukhikh

Email: ncagp@bk.ru

E A Kogan

T A Demura

D Yu Trofimov

A E Donnikov

M I Kesova

A I Martynov

O V Bolotova

N E Kan

N V Ordzhonikidze

G T Sukhikh

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Ye A Kogan

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

T A Demura

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

D Yu Trofimov

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

A Ye Donnikov

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

M I Kesova

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

A I Martynov

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

O V Bolotova

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

N E Kan

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

N V Ordzhonikidze

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

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