Prediction of the outcomes of pregnancy and labor in acute gestational pyelonephritis

The purpose of the study was to determine criteria for predicting the development of pregnancy and labor and perinatal outcomes in acute gestational pyelonephritis, by determining genetic markers (GPIIIα gene) and immunological predictors (ELI-P-Test). One hundred and twenty women with acute gestational pyelonephritis first diagnosed at 7-27 weeks of gestation were examined. The course of pregnancy and labor and fetal status were retrospectively assessed without using the prognostic criteria in 60 control patients (Group 1); prediction was made on the basis of immunogenetic studies in 60 pregnant women (Group 2). In the latter group, the frequency of obstetric complications was higher in the GP IIIα gene PL-AII allele carriers who were hyperreactive at the ELI-P-Test than that in the PL-AI allele ones. The greater the deviations from the normal ELI-P-Test values were, the severer acute gestational pyelonephritis was. In acute gestational pyelonephritis, there was a clear correlation between the frequency of pregnancy complications and the severity of the disease, the allele affiliation by the GPIIIα gene and the serum autoantibody levels as evidenced by the ELI-P-Test.

acute gestational pyelonephritis, placental insufficiency, gestosis