Tuboperitoneal infertility: clinical value of determination of vascular endothelial growth factor in the prediction of ovarian hyperstimulation syndrome
- Authors: Komissarova Y.V1, Kuz'michev LN1, Komissarova Y.V1, Kuzmichev LN1
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- Issue: No 4 (2010)
- Pages: 50-54
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246360
- ID: 246360
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Abstract
Ovarian hyperstimulation syndrome (OHS) is an iatrogenic condition the pathogenesis of which involves generalized endothelial dysfunction. According to different authors' data, the incidence of severe OHS ranges from 0.01 to 15% per ovulation induction cycle. The objective of the study was to develop additional prognostic criteria for severe OHS in an assisted reproduction technology (ART) program. The time course of changes in serum vascular endothelial growth factor (VEGF) in the ART program was studied in 182 reproductive-aged patients at risk for OHS. There was a significant increase in the blood level of VEGF-A before administration of an ovulation trigger and on the day of follicular puncture in the further development of severe OHS versus a group without OHS. An early prognostic criterion for severe OHS was elaborated and proposed on the basis of biochemical laboratory diagnostic tests.
References
- Манухин И.Б., Макарищев А. Я., Геворкян М. А. и др. Сосудистый эндотелиальный фактор роста и синдром поликистозных яичников // Пробл. репрод. - 2007. - № 5. - С. 41-46.
- Назаренко Т.А. Стимуляция функции яичников. - М., 2008. - С. 180-196.
- Регистр центров ВРТ в России. Отчет о НИР за 2006 год Российской ассоциации репродукции человека // Пробл. репрод. - 2008. - № 6. - С. 8-23.
- Стрижаков А.Н., Кушлинский Н.Е., Тимохина Е.В. и др. Роль ангиогенных факторов роста в прогнозировании плацентарной недостаточности // Вопр. гин., акуш. и перинатол. - 2009. - № 4. - С. 5-11.
- Сухих Г.Т. , Сароян Т.Т., Корнеева И.Е. Иммунные аспекты патофизиологии синдрома гиперстимуляции яичников // Акуш. и гин. - 2009. - № 3. - С. 3-6.
- Флетчер Р., Флетчер С., Вагнер Э. Клиническая эпидемиология: основы доказательной медицины. - М., 2004. - С. 152-188.
- Bourlev V., Volkov N., Pavlovitch S. et al. The relationship between microvessel density, proliferative activity and expression of vascular endothelial growth factor-A and its receptors in eutopic endometrium and endometriotic lesions // Reproduction. - 2006. - № 3. - P. 501-509.
- Ebisch I., Thomas C., Wetzels A. et al. Review of the role of the plasminogen activator system and vascular endothelial growth factor in subfertility // Fertil. Steril. - 2008. - № 6. - P. 2340-2350.
- Koo Y., Lee B., Park H. et al. Altered vascular endothelial growth factor expression during GnRH antagonist protocol in women of reproductive age with normal baseline hormone profiles // Fertil. Steril - 2009. - № 3. - P. 744-748.
- Rizk B. Оvarian hyperstimulation syndrome: epidemiology, pathophysiology, prevention and management. − New York, 2006. - P. 48-67.
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