Differential approach to therapy for bleeding in the first trimester of pregnancy after in vitro fertilization and embryo transfer


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Abstract

Clinical laboratory examination was made in 74 women with singleton and multiple pregnancy occurring after in vitro fertilization (IVF) and embryo transfer (ET). Following IVF, the level of progesterone in women with pregnancy complicated and uncomplicated by bleeding was 5-6 times greater than the physiological parameters. These changes impair the protective-adaptive mechanisms of hemostasis and cause thrombophilic changes and, as a result of these diseases, chorionic detachment and formation of retrochorial hematomas, and the development of primary placental insufficiency. An algorithm for treatment is given in relation to the cause of bleeding (embryo reduction, chorionic detachment, chorionic presentation).

About the authors

Viktoriya Viktorovna Gnipova

Email: ncagp@bk.ru

V M Sidel'nikova

V V Gnipova

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

V M Sidelnikova

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow

References

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