Results of pre-implantation diagnosis by the FISH technique in married couples with normal karyotype

Preimplantation diagnosis (PD) using the molecular cytogenetic FISH technique was made in 37 married couples with infertility in the 41st superovulation induction cycle. The rate of aneuploidy for chromosomes 13, 21 in embryos was 38,2%; that for chromosomes X, Y, and 21 was 30.4%. In simultaneous aneuploidy for different chromosomes, the discordance in morphological structure differs more frequently than in aneuploidy for one chromosome: from 37.5% (in the study of chromosomes X, Y, 21) to 40% (in the study of chromosomes 13, 21) versus 16.7 and 35%, respectively. The PD technique is highly effective in preventing the birth of a genetically ill offspring.

preimplantation diagnosis, aneuploidy, FISH technique, normal karyotype