Premenstrual dysphoric disorder: a role of serotonin in diagnosis and treatment policy


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Fifty women with the neuropsychic form of premenstrual syndrome (PMS), including 15 patients with premenstrual disphoric disorder, were studied. Yarina containing ethynylestradiol 30 μg and drospirenone 3 mg was used to treat this condition. In PMS, the blood content of serotonin was found to be less than that in healthy women; in its severe form (0.26 μM/l), it was less than in its mild form. After treatment serotonin levels was increased by approximately by 3 times. Most patients were observed to have a significant reduction in the symptoms of PMS, including in the severe form of the disease. Low blood serotonin concentrations may serve as a prognostic sign of the insufficient efficiency of drospirenone therapy.

Sobre autores

T Lekareva

Marina Tarasova

Email: tarasova@ott.ru

T Lekareva

D. O. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, Saint Petersburg

D. O. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, Saint Petersburg

M Tarasova

D. O. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, Saint Petersburg

D. O. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, Saint Petersburg

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