Plasmapheresis and immunoglobulin therapy in the complex treatment of rhesus sensitization
- Authors: Fedorova TA1, Mitrya IV1
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Affiliations:
- Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow
- Issue: No 1 (2010)
- Pages: 38-42
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246434
- ID: 246434
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Abstract
One hundred and forty-seven pregnant women with rhesus sensitization with a rhesus antibody titer of higher than 1:32 were examined. A study group comprised 87 women who received complex therapy involving plasmaferesis (PA) and immunoglobulin therapy. A control group included 60 pregnant women with rhesus sensitization. The study indicated that a course of medium-volume PA followed by immunoglobulin therapy resulted in reduced and stabilized rhesus antibody titers, which reduced the number of preterm labors by 2.6 times, the rate of birth of babies with the moderate and severe forms of neonatal hemolytic disease by 2.5 times, the duration of phototherapy by 1.4 times, thus lowering prenatal morbidity rates. The complex treatment of rhesus sensitization, by using PA and immunoglobulin therapy, was found to be an effective method for the prevention of fetal and neonatal hemolytic disease.
About the authors
T A Fedorova
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow
Email: ncagp@bk.ru
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow
I V Mitrya
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow
Email: ncagp@bk.ru
Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russian Agency for Medical Technologies, Moscow
References
- Ветров В. В. Эфферентная терапия и аутодонорство в акушерском стационаре. - СПб., 2008. - С. 65-72.
- Донсков С. И. Группы крови системы Rhesus. - М., 2005. - С. 133-146.
- Минеева Н. В. Группы крови человека. - СПб., 2004. - С. 53-75, 157-179.
- Рогачевский О. В. // АГ-инфо: Журн. Рос. о-ва акуш.-гин. - 2006. - № 2. - С. 35-38.
- Савельева Г. М., Федорова М. В., Клименко П. А. Плацентарная недостаточность. - М., 1991. - С. 23, 26-28, 33- 34, 70, 82-83.
- Сидельникова В. М., Антонов А. Г. Гемолитическая болезнь плода и новорожденного. - М., 2004. - С. 10-52, 129- 135.
- Armour K. L., Parry-Jones D., Beharry N. et al. // Blood. - 2006. - Vol. 107, N 7. - P. 2619-2626.
- Beliard R., Waegemans T., Notelet D. et al. // Br. J. Haematol. - 2008. - Vol. 141, N 1. - P. 109-119.
- Greenough A. // BioDrugs. - 2001. - Vol. 15, N 8. - P. 533-541.
- Heyman B. // Ann. Rev. Immunol. - 2000. - Vol. 18. - P. 709-737.
- Iida Sh., Misaka H., Inoue M. et al. // Clin. Cancer Res. - 2006. - Vol. 12, N 9. - P. 2879-2887.
- Murray N. A., Roberts I. A. // Arch. Dis. Child Fetal Neonat. - 2007. - Vol. 92. - P. 83-88.
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