CAN THE FMR1 GENE BE CONSIDERED AS A PREDICTOR OF EARLY OVARIAN AGING?


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The review considers the role of various genetic causes of premature ovarian aging with considerable attention given to the FMR1 gene located on the X chromosome long arm at Xg27.3. It has been ascertained that the CGG repeat length of the FMR1 gene may be one of the early objective predictors that indicate the risk of premature ovarian failure and may serve as a new test for predicting ovarian functional activity.

Full Text

Restricted Access

About the authors

N. N SHAMILOVA

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: drshamilova@gmail.com

L. A MARCHENKO

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

References

  1. Мишиева Н.Г. Бесплодие у женщин позднего репродуктивного возраста: принципы диагностики и лечения в зависимости от овариального резерва: Дис.. д-ра мед. наук — М., 2008. — С. 168-176.
  2. Табеева Г.И. Оценка андрогенного статуса при преждевременной недостаточности яичников и дифференцированный подход к лечению: Дис.. канд. мед. наук — М., 2009. — С. 85-86.
  3. Allen E.G., Sullivan A.K., Marcus M. et al. Examination of reproductive aging milestones among women who carry the FMR1 premutation // Hum. Reprod. — 2007. — Vol. 22, № 8. — P. 2142-2152.
  4. Bodega B., Bione S., Dalpra L. et al. Influence of intermediate and uninterrupted FMR1 CGG expansions in premature ovarian failure manifestation // Hum. Reprod. — 2006. — Vol. 21. - P. 952—957.
  5. Bretherick K.L., Fluker M.R., Robinson W.P. FMR1 repeat sizes in the gray zone and high end of the normal range are associated with premature ovarian failure // Hum. Genet. — 2005. — Vol. 117. — P. 376 —378.
  6. Chen L.S., Tassone F., Sahota P., Hagerman P.J. The (CGG) n repeat element within the 5' untranslated region of the FMR1 message provides both positive and negative cis effects on in vivo translation of a downstream reporter // Hum. Mol. Genet. — 2003. — Vol. 12. — P. 3067—3074.
  7. Edward E. Wallach. The FMR1 premutation and reproduction // Fertil. and Steril. — 2007. — Vol. 87. — P. 456—465.
  8. Faddy M.J., Gosden R.G. Modelling the dynamics of ovarian follicle utilization throughout life // Biology and pathology of the oocyte: its role in fertility and reproductive medicine. -Cambridge: Cambridge University, United Kingdom, 2003. — Pt. 2. — P. 44-52.
  9. Gleicher N., Weghofer A., Oktay K., Barad D.H. Can the FMR1 (fragile X) gene serve as predictor of response to ovarian stimulation? // Reprod. Sci. - 2009. — Vol. 16. — P. 462—467.
  10. Gleicher N., Weghofer A., Barad D.H. A pilot study of premature ovarian senescence: II. Different genotype and phenotype for genetic and autoimmune etiologies // Fertil. and Steril. — 2009. — Vol. 91, № 5. — P. 1707-1711.
  11. Gleicher N., Weghofer A., Oktay K., Barad D.H. Correlation of triple repeats on the FMR1 (fragile X) gene to ovarian reserve: a new infertility test? // Acta Obstet. Gynecol. Scand. — 2009. — Vol. 88. — P. 1024—1030.
  12. Gleicher N., Weghofer A., Barad D.H. Effects of race/ethnicity on triple CGG counts on FMR1 gene in infertile women and egg donors // Reprod. Biomed. Online. — 2010. — Vol. 20, № 4. — P. 485-491.
  13. Gleicher N., Weghofer A., Barad D.H. Ovarian reserve determinations suggest new function of FMR1 (fragile X) gene in regulating ovarian aging // Reprod. Biomed. Online. — 2010. — Vol. 20, № 6. — P. 768-775.
  14. Knauff Erik A.H. Premature ovarian failure from phenotype to genotype. - Amsterdam: Thesis, Utrecht University, the Netherlands, 2009. — P. 9-27.
  15. Méduri G., Massin N., Guibourdenche J. et al. Serum anti-Müllerian hormone expression in women with premature ovarian failure // Hum. Reprod. — 2007. — Vol. 22, № 1. — P. 117-123.
  16. Nelson L.M. Clinical practice. Primary ovarian insufficiency // N. Engl. J. Med. — 2009. — Vol. 360. — P. 606—614.
  17. Nikolaou D., Templeton A. Early ovarian ageing // Eur. J. Obstet. Gynecol. Reprod. Biol. — 2004. — Vol. 113. — P. 126—133.
  18. Welt C.K., Smith P.C., Taylor A.E. Evidence of early ovarian aging in fragile X premutation carriers // J. Clin. Endocrinol. Metab. — 2004. — Vol. 89, № 9. — P. 4569-4574.
  19. Wittenberger M.D., Hagerman R.J., Sherman S.L. et al. The FMR1 premutation and reproduction // Fertil. and Steril. — 2007. — Vol. 87. — P.456—465.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2011 Bionika Media