RENAL IMMUNOMORPHOLOGY AFTER PRIOR PREECLAMPSIA
- Authors: MURASHKO L.E1, ILYINSKY I.M2
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Affiliations:
- Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
- V.I. Shumakov Federal Research Center for Transplantation and Artificial Organs
- Issue: No 3 (2011)
- Pages: 23-26
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246479
- ID: 246479
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Abstract
Twenty women with a history of preeclampsia and perinatal losses were examined. Renal biopsy specimens were studied in 17 women at 8 days to 1.5 years after pregnancy completion. Their histological study revealed morphological changes in 7(41.2%) women, which allowed one to think that they had chronic kidney diseases that had been previously unrecognized and erroneously taken as preeclampsia. Fifteen (88.2%) of the 17 women with a history of preeclampsia were found to have the major immunoglobulin classes G, M, A, and complement component C3 in the kidney, which confirms one of the main points of the development of preeclampsia, according to which circulating immune complexes are deposited in the vital organs and exert damaging effects on the latter.
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About the authors
L. E MURASHKO
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
I. M ILYINSKY
V.I. Shumakov Federal Research Center for Transplantation and Artificial Organs
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