IGG SUBCLASSES DISTRIBUTION AND PATHOGENETIC ACTIVITY OF AUTOANTIBODIES TO HUMAN CHORIONIC GONADOTROPIN N WOMEN WITH A HISTORY OF REPRODUCTIVE FAILURE
- Authors: MENZHINSKAYA I.V1
-
Affiliations:
- Issue: No 3 (2011)
- Pages: 32-36
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246486
- ID: 246486
Cite item
Open Access
Access granted
Abstract
Objective. To study the IgG subclass distribution and avidity of anti-human chorionic gonadotropin autoantibodies (anti-hCG) in women with reproductive failure in order to evaluate their pathogenetic activity. Subjects and methods. A study group included 83 women with anti-hCG IgG, of them there were 46 (55.4%) and 25 (30.1%) with a history of miscarriage and infertility, respectively. Their sera were tested for IgG subclasses (1—4) of anti-hCG, as well as circulating immune complexes (CIC) (CIC-C1q, CIC-C3d) by enzyme-linked immunosorbent assay. Results. IgG1, IgG2 and IgG4 subclasses of anti-hCG with a high avidity index were most common in the study group; different spectra of IgG subclasses were observed. There was a preponderance of IgG1 — the latter was seen in 66 (79.5%). Highly avid IgG1 and/or IgG2 were detected significantly more frequently in women with first-trimester spontaneous or threatened abortion after use of assisted reproductive technology for infertility. The mechanisms responsible for immunopathogenesis in the production of anti-hCG are assumed to comprise the activation of the complement system and effector cells. Conclusion. Estimation of the pathogenetic activity of anti-hCG, by determining avidity and IgG subclasses may be of practical significance in the prediction of the course of pregnancy and the development of reproductive failure.
Full Text
References
- Кирющенков П.А. Состояние репродуктивной функции и тактика ведения женщин с аутосенсибилизацией к хорионическому гонадотропину человека: Автореф. дис. д-ра мед. наук. — М., 2001.
- Кирющенков П.А., Сухих Г.Т., Ванько Л.В. и др. Клинико-иммунологическое значение аутоантител к хорионическому гонадотропину при невынашивании беременности // Акуш. и гин. — 1996. — № 4. — С. 14—16.
- Пономарева И.В., Сухих Г.Т., Никитин Э.Б. и др. Аутоантитела к хорионическому гонадотропину человека при привычном невынашивании беременности // Бюл. экспер. биол. и мед. — 1996. — № 4. — C. 450—452.
- Цырлина Е.В., Порошина Т.Е. Хорионический гонадотропин как маркер трофобластической болезни // Практическая онкол. — 2008. — Т. 9, № 3. — С. 150—159.
- Aalberse R.C., Stapel S.O., Schuurman J., Rispens T. Immunoglobulin G4: an odd antibody // Exp. Allergy. — 2009. — Vol. 39. — P. 469—477.
- Amato F., Warnes G.M., Kirby C.A. et al. Infertility caused by hCG autoantibody // J. Clin. Endocrinol. Metabol. — 2002. — Vol. 87, № 3. — P. 993—997.
- Cervera R., Balasch J. Bidirectional effects on autoimmunity and reproduction // Hum. Reprod. Update. — 2008. - Vol. 14, № 4. — P. 359—366.
- Cole L.A. New discoveries on the biology and detection of human chorionic gonadotropin // Reprod. Biol. Endocrinol. — 2009. — Vol.7, № 8. — P. 1—37.
- Deshmukh U.S., Talwar G.P., Gupta S.K. IgG subclass distribution of anti-hCG and antidiphtheria toxoid antibodies in women immunized with a β-hCG based immunocontraceptive vaccine // J. Reprod. Immunol. — 1994. — Vol. 26. — P. 65—72.
- Forges T., Monnier-Barbarino P., Faure G.C., Bene M.C. Autoimmunity and antigenic targets in ovarian pathology // Hum. Reprod. Update. — 2004. — Vol. 10, № 2. — P. 163—175.
- Haller K., Mathieu C., Rull K. et al. IgG, IgA and IgM antibodies against FSH: serological markers of pathogenic autoimmunity or of normal immunoregulation? // Amer. J. Reprod. Immunol. — 2005. — Vol. 54. — P. 262—269.
- Hamilton R.G. Human IgG subclass measurement in the clinical laboratory // Clin. Chem. — 1987. — Vol. 33, № 10. — P. 1707—1725.
- Pala A., Coghi I., Spampinato G., et al. Immunochemical and biological characteristics of a human autoantibody to human chorionic gonadotropin and luteinizing hormone // J. Clin. Endocrinol. Metabol. — 1988. — Vol. 67, № 6. — P. 1317—1321.
- Salmon J.E., Pricop L. Human receptors for immunoglobulin G // Arthritis and Rheumatism. — 2001. — Vol. 44, № 4. — P. 739—750.
- Schroeder H.W.Jr., Cavacini L. Structure and function of immunoglobulins // J. Allergy Clin. Immunol. — 2010. — Vol. 125, № 2, suppl. 2. — P. 41—55.
- Stevens V.C. Current status of antifertility vaccines using gonadotrophin immunogens // Immunol. Today. — 1986. — Vol. 7. — P. 369—374.
- Talwar G.P., Singh Om, Pal R. et al. A vaccine that prevents pregnancy in women // Proc. Natl. Acad. Sci. USA. — 1994. — Vol. 91. — P. 8532—8536.
- Tsampalas M., Gridelet V., Berndt S. et al. Human chorionic gonadotropin: A hormone th immunological and angiogenic properties // J. Reprod. Immunol. — 2010. — Vol. 85. — P. 93—98.
Supplementary files
