PHENOTYPIC AND FUNCTIONAL CHARACTERISTICS OF NK CELLS IN PREGNANCY


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Abstract

The review considers an update on the functional characteristics of natural killer (NK) cells and their involvement in the mechanisms of the physiological course of pregnancy and the formation of placental tissue. It also discusses NK cell functional impairments in gestosis and miscarriage.

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About the authors

V. A MIKHAYLOVA

D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch of the Russian Academy of Medical Science

S. A SELKOV

D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch of the Russian Academy of Medical Science

Email: selkovsa@mail.ru

D. I SOKOLOV

D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch of the Russian Academy of Medical Science

References

  1. Айламазян Э.К., Мозговая Е.В. Гестоз: теория и практика. - М.: Медпресс-информ, 2008.
  2. Заболевания иммунной системы: Диагностика и фармакотерапия/ Н.М.Калинина, С.Н. Шуленин, С.А. Кетлинский и др. - М.: ЭКСМО, 2008.
  3. Иммунологическая загадка беременности/ Н.Ю. Сотникова, Ю.С. Анциферова, А.В. Кудряшова и др. -Иваново: МИК, 2005.
  4. Сельков С.А., Павлов О.В. Плацентарные макрофаги. — М.: Товарищество научных изданий КМК, 2007.
  5. Соколов Д.И., Селютин А.В., Лесничая М.В. и др. Субпопуляционный состав лимфоцитов периферической крови беременных женщин с гестозом // Журн. акуш. и жен. бол. — 2007. — Т. 56, № 4. — С. 17—23.
  6. Barber D.F., Faure M., Long E.O. LFA-1 contributes an early signal for NK cell cytotoxicity // J. Immunol. — 2004. — Vol. 173. — P. 3653-3659.
  7. Carayannopoulos L.N., Barks J.L., Yokoyama W.M. et al. Murine trophoblast cells induce NK cell interferon-gamma production through KLRK1 // Biol. Reprod. — 2010. — Vol. 83. — P. 404—414.
  8. Carlino C., Stabile H., Morrone S. et al. Recruitment of circulating NK cells through decidual tissues: a possible mechanism controlling NK cell accumulation in the uterus during early pregnancy // Blood. — 2008. — Vol. 111. — P. 3108-3115.
  9. Coupel S., Moreau A., Hamidou M. et al. Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation // Blood. — 2007. — Vol. 109. — P. 2806-2814.
  10. Dosiou C., Giudice L.C. Natural killer cells in pregnancy and recurrent pregnancy loss: endocrine and immunologic perspectives // Endocr. Rev. — 2005. — Vol. 26, № 1. — P. 44-62.
  11. Estefama E., Flores R., Gomez-Lozano N. et al. Human KIR2DL5 is an inhibitory receptor expressed on the surface of NK and T lymphocyte subsets //J. Immunol. — 2007. — Vol. 178. — P. 4402—4410.
  12. Ferlazzo G., Thomas D., Lin S.L. et al. The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic // J. Immunol. — 2004. — Vol. 172. — P. 1455-1462.
  13. Flores A.C., Marcos C.Y., Paladino N. et al. KIR receptors and HLA-C in the maintenance of pregnancy // Tiss. Antigens. — 2007. — Vol. 69. — P. 112—113.
  14. Freud A.G., Becknell B., Roychowdhury S. et al. A human CD34(+) subset resides in lymph nodes and differentiates into CD56 bright natural killer cells // Immunity. — 2005. — Vol. 22. — P. 295-304.
  15. Hanna J., Wald O., Goldman-Wohl D. et al. CXCL12 expression by invasive trophoblasts induces the specific migration of CD16- human natural killer cells // Blood. — 2003. — Vol. 102. — P. 1569-1577.
  16. Heazell A.E.P. Altered expression of regulators of caspase activity within trophoblast of normal pregnancies and pregnancies complicated by preeclampsia // Reprod. Sci. — 2008. — Vol. 15. — P. 1034—1043.
  17. Hu Y., Dutz J.P., MacCalman C.D. et al. Decidual NK cells alter in vitro first trimester extravillous cytotrophoblast migration: a role for IFN-y // J. Immunol. — 2006. — Vol. 177. — P. 8522-8530.
  18. Keskin D.B., Allan D.S.J., Rybalov B. et al. TGFß promotes conversion of CD16+ peripheral blood NK cells into CD16-NK cells with similarities to decidual NK cells // Proc.Natl. Acad. Sci. USA. — 2007. — Vol. 104, № 9. — P. 3378-3383.
  19. King K., Smith S., Chapman M. et al. Detailed analysis of peripheral blood natural killer (NK) cells in women with recurrent miscarriage // Hum. Reprod. — 2010. — Vol. 25, № 1. — P. 52-58.
  20. Kopcow H.D., Karumanchi S.A. Angiogenic factors and natural killer (NK) cells in the pathogenesis of preeclampsia // J. Reprod. Immunol. — 2007. — Vol. 76, № 1—2. — P. 23-29.
  21. Krzewski K., Strominger J.L. The killer’s kiss: The many functions of NK cell immunological synapses // Curr. Opin. Cell Biol. — 2008. — Vol. 20, № 5. — P. 597-605.
  22. LeMaoult J., Zafaranloo K., Le Danff C. et al. HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells // FASEB J. — 2005. — Vol. 24. — P. 662—664.
  23. Liang S., Ristich V., Arase H. et al. Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6— STAT3 signaling pathway // Proc.Natl.Acad.Sci. USA— 2008. — Vol. 105, № 24. — P. 8357-8362.
  24. Loza M.J., Perussia B. The IL-12 signature: NK cell terminal CD56+high stage and effector functions // J. Immunol. — 2004. — Vol. 172. — P. 88-96.
  25. Minas V., Jeschke U., Kalantaridou S.N. et al. Abortion is associated with increased expression of FasL in decidual leukocytes and apoptosis of extravillous trophoblasts: a role for CRH and urocortin // Mol. Hum. Reprod. — 2007. — Vol. 13, № 9. — P. 663—674.
  26. Mirandola P., Ponti C., Gobbi G. et al. Activated human NK and CD8+ T cells express both TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors but are resistant to TRAIL-mediated cytotoxicity // Blood. — 2004. — Vol. 104, № 8. — P.2418—2424.
  27. Moesta A.K., Norman P.J., Yawata M. et al. Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3 // J. Immunol. — 2008. — Vol. 180. — P. 3969 -3979.
  28. Morel E., Bellon T. HLA class I molecules regulate IFN-а production induced in NK cells by target cells, viral products, or immature dendritic cells through the inhibitory receptor ILT2/CD85j //J. Immunol. — 2008. — Vol. 181. — P. 23682381.
  29. Quenby S., Nik H., Innes B. et al. Uterine natural killer cells and angiogenesis in recurrent reproductive failure // Hum. Reprod. — 2009. — Vol. 24, № 1. — P. 45—54.
  30. Rajagopalan S., Bryceson Y.T., Kuppusamy S.P. et al. Activation of NK cells by an endocytosed receptor for soluble HLA-G // PLoS Biol. — 2006. — Vol. 4, № 1. — P. 70-86.
  31. Roda—Navarro P., Vales-Gomez M., Chisholm S.E. et al. Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function // Proc.Natl.Acad.Sci. USA. — 2006. — Vol. 103, № 30. — P. 11258-11263.
  32. Saito S., Shiozaki A., Nakashima A. et al. The role of the immune system in preeclampsia // Mol. Aspects Med. - 2007. - Vol.28. - P. 192-209.
  33. Straszewski-Chavez S.L., Abrahams V.M., Funai E.F. et al. X-linked inhibitor of apoptosis (XIAP) confers human trophoblast cell resistance to Fas-mediated apoptosis // Mol. Hum. Reprod. — 2004. — Vol. 10, № 1. — P. 33—41.
  34. Tabiasco J., Rabota M., Aguerre-Girr M. et al. Human decidual NK cells: unique phenotype and functional properties // Placenta. — 2006. — Vol. 27. — P. S34-S39.
  35. Tessmer M.S., Fugere C., Stevenaert F. et al. KLRG1 binds cadherins and preferentially associates with SHIP-1 // Int. Immunol. — 2007. — Vol. 19, № 4. — P. 391-400.
  36. Van der Meer A., Lukassen H.G.M., van Lierop M.J.C. et al. Membrane-bound HLA-G activates proliferation and interferon-g production by uterine natural killer cells // Mol. Hum. reprod. — 2004. — Vol. 10, № 3. — P. 189-195.
  37. Vitale M., Carlomagno S., Falco M. et al. Isolation of a novel KIR2DL3-specific mAb: comparative analysis of the surface distribution and function of KIR2DL2, KIR2DL3 and KIR2DS2 // Int. Immunol. — 2004. — Vol. 16, № 10. — P. 1459-1466.
  38. Woodfin A., Voisin M.-B., Nourshargh S. PECAM-1: a multifunctional molecule in inflammation and vascular biology // Arterioscler. Thromb.Vasc. Biol. — 2007. — Vol.27. — P. 2514—2523.
  39. Wu X., Jin L.P., Yuan M.M. et al. Human first-trimester trophoblast cells recruit CD56 bright CD16- NK cells into decidua by way of expressing and secreting of CXCL12/ stromal cell-derived factor 1 //J. Immunol. — 2005. — Vol. 175. — P. 61-68.
  40. Yawata M., Yawata N., Draghi M. et al. Roles for HLA and KIR polymorphisms in natural killer cell repertoire selection and modulation of effector function // J. Exp. Med. — 2006. — Vol. 203, № 3. — P. 633-645.

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