THE FREQUENCY OF HEMORRHAGIC MANIFESTATIONS IN EXTREMELY PREMATURE INFANTS


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Abstract

Objective. To define the frequency of hemorrhagic complications in extremely premature infants and their relationship to body weight and gestational age and to assess the role of these complications in tanatogenesis in case of fatal outcomes. Materials and methods. Five hundred and seven case histories of extremely premature infants admitted to the neonatal intensive care unit in 1997 to 2009 were analyzed retrospectively and prospectively. Three hundred and forty-two case histories were analyzed after 165 patients were excluded from the study due to the fact that they did not meet the inclusion criteria for the purpose in hand. Results. The authors established the frequency of hemorrhagic complications, their relationship, a correlation between hemorrhagic complications and birth weight and gestational age, as well as the role of individual nosological entities in tanatogenesis. Conclusion. Our study has provided evidence that infants of 24-26 weeks gestation are susceptible to hemorrhagic manifestations. The found correlations between hemorrhagic complications of various sites and disseminated intravascular coagulation (DIC) suggest that the complications are of considerable importance in manifesting DIC. A significant predominance of hemorrhagic syndrome in dead versus surviving patients permits the assumption of the important role of these manifestations in tanatogenesis.

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About the authors

L. B ALIEVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia, Moscow

Email: alieva_1@mail.ru

A. G ANTONOV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia, Moscow

A. S BURKOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia, Moscow

A. A LENYUSHKINA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia, Moscow

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