ROLE OF ESTROGEN RECEPTOR-ALPHA (ESR1) GENE POLYMORPHISM IN INADEQUATE UTERINE SCAR FORMATION AFTER CESAREAN SECTION


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Abstract

Objective. To search for associations of ESR1 gene polymorphism with the morphological and clinical signs of uterine scar inadequacy after previous cesarean section. Subjects and methods. One hundred and sixty patients with post-cesarean uterine scar were examined. According to biopsy specimen morphological evidence, the authors identified 2 groups: 1) 80 patients with inadequate scars and 2) 80 patients with adequate ones. ESR1 gene polymorphisms, such as Ser10Ser 30A>G (rs2077647/ rs17847075), Pvull -397 T>C (rs2234693), Xbal -351G>A, (rs9340799), Thr594Thr 2014G>A (rs2228480), and 1029C>T(rs3798577), were defined. Results. Analysis of individual ESR1 gene loci revealed no statistically significant association between the status of a scar and the genotype distribution of the study polymorphisms. However, an analysis of the linkage of the chosen polymorphisms showed its most significant disequilibrium between the polymorphisms -397 T>C (Pvull) and -351 G>A (Xbal) D’=0.991 (0.95—1.00), LOD=16.98. The frequency of the CA haplotype was substantially higher in women with the signs of scar tissue inflammation (17.2 versus 5.4%; p=0.046). The odds ratio for scar inadequacy in carriage of this haplotype was 3.7 (1.0—14.0). Conclusion. According to the ESR1 polymorphisms -397 T>C (Pvull) and -351 G>A (Xbal), CA haplotype carriage is a risk factor for inadequate scar formation after cesarean section.

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G. T SUKHIKH

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

M. I KESOVA

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

A. E DONNIKOV

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

N. E KAN

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: n_kan@oparina4.ru

O. V BOLOTOVA

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

E. A KOGAN

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

T. A DEMURA

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

I. V KLIMANTSEV

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

E. Yu AMIRASLANOV

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

M. V SANNIKOVA

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

D. D ABRAMOV

ZAO «NPF DNA Technology», Moscow

V. V KADOCHNIKOVA

ZAO «NPF DNA Technology», Moscow

N. V ORDZHONIKIDZE

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

D. Yu TRIFONOV

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

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