THE RATE OF MONOCYTE LIPID ABSORPTION IN PREGNANT WOMEN


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Objective. To study the rate of peripheral blood monocyte absorption of lipids from the autologous sera of healthy nonpregnant women, women with physiological pregnancy, and pregnant women with gestosis. Material and methods. Peripheral blood monocytes were cultured for 24 hours in the presence of autologous sera and stained with OIL RED O (ICN, USA) to detect intracellular lipids. The levels of intracellular lipids were estimated by a computer imaging system and the Morphology 4.0 program (Videotest, Russia). Results. The rate of peripheral blood monocyte lipid absorption from the sera of pregnant women with gestosis was signif icantly higher than that in healthy pregnant and non-pregnant women. The fact that the peripheral blood monocytes obtained from patients with gestosis give rise to foamy cells suggests their activation and possible role in the development of generalized endothelial dysfunction.

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作者简介

O. STEPANOVA

D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch of the Russian Academy of Medical Science

D. SOKOLOV

D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch of the Russian Academy of Medical Science

M. LESNICHIYA

D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch of the Russian Academy of Medical Science

T. LVOVA

D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch of the Russian Academy of Medical Science

M. MIRASHVILI

D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch of the Russian Academy of Medical Science

O. ARZHANOVA

D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch of the Russian Academy of Medical Science

I. KVETNOY

D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch of the Russian Academy of Medical Science

S. SELKOV

D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch of the Russian Academy of Medical Science

Email: selkovsa@mail.ru

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