FLUORESCENCE DIAGNOSIS AND PHOTODYNAMIC THERAPY FOR VULVAR CONDYLOMATA ACUMINATA
- Authors: DENISOVA E.D1,2, APOLIKHINA I.A1,2, BULGAKOVA N.N3
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Affiliations:
- Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
- I.M. Sechenov First Moscow State Medical University
- A.M. Prokhorov Institute of General Physics, Russian Academy of Sciences
- Issue: No 8 (2011)
- Pages: 112-116
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246662
- ID: 246662
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Abstract
Objective. To study the efficiency of the fluorescence diagnosis (FD) and photodynamic therapy (PDT) of vulvar condylomata acuminata (CA), by using the endogenous photosensitizer protoporphyrin IX, the synthesis of which occurs in the use of oral and topical 5-aminolevulinic acid (5-ALA). Subjects and methods. Eighty-six patients with vulvar CA were examined and treated. For FD and PDT, the authors used alasens that contained the standard substance of 5-ALA. Results. During FD, the red fluorescence of protoporphyrin IX was recorded not only in CA, but also in the hidden, invisible in white light, foci of human papillomavirus infection, which further developed to the clinical form of papillomavirus infection. The FD and PDT of vulvar CA were shown to result in a clinical resolution in 70—73% of cases and to reduce the number of recurrences by 5-fold as compared to chemical destruction. Conclusion. FD and PDT can be regarded as an alternative method for the diagnosis and treatment of vulvar CA.
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About the authors
E. D DENISOVA
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia; I.M. Sechenov First Moscow State Medical University
I. A APOLIKHINA
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia; I.M. Sechenov First Moscow State Medical University
N. N BULGAKOVA
A.M. Prokhorov Institute of General Physics, Russian Academy of Sciences
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