PATHOGENETIC TREATMENT FOR BACTERIAL DYSBIOSES

Objective. To establish the eff iciency of two-step treatment in women with new-onset and recurrent bacterial vaginosis. Subjects and methods. The study included 70 patients aged 35 to 45 years with bacterial vaginosis. Its diagnosis was made on the basis of clinical data, Amsel’s diagnostic criteria, the results of vaginal smear microscopy and vaginal discharge culture study. All the studies were conducted before and after two-step treatment with fluomizin and gynoflor E. Results. Gardnerella vaginalis that had been found in none patient in Group 1 and preserved in 2 (7.1%) patients in Group 2 proved to be most susceptible to the drugs. Anaerobic cocci and enterococci were isolated in the low titer of 10 2—10 3 CFU/ml in 7.1 and 11.9% of Group 1 women, respectively, which was 5 times less than those prior to treatment. The drug was highly effective against Escherichia coli and staphylococci. The colonization exceeded 103 CFU/ml only in 4 out of 42 women. The drug also exerted a considerable inhibitory effect on the growth of Candida fungi; the latter were not detected in Group 1 women posttreatment, but were only in 1 (3.5%) in Group 2. There was a posttreatment preponderance of lactobacteria in the vaginal discharge in 95.2 and 92.8% in Groups 1 and 2 women, respectively. Conclusion. The study demonstrated the efficiency of the first step of treatment with the antiseptic fluomizin and that of the second step that recovered biocenosis with gynoflor E that contained viable lactobacteria and a microdose of estriol.

new-onset bacterial vaginosis, recurrent bacterial vaginosis, efficiency, fluomizin, gynoflor E