FERTILITY RECOVERY IN WOMEN WITH GENITAL ENDOMETRIOSIS


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The paper gives the current views of the pathogenesis of endometriosis, the mechanisms responsible for the development of infertility in this disease, and therapeutic approaches with regard to the necessity of fertility recovery. It shows that it is expedient to make the stepwise management of patients with genital endometriosis, which comprises suppressive therapy with gonadotropin-releasing hormone agonists with further pregravid preparation with progestagens.

Full Text

Restricted Access

About the authors

I. V KUZNETSOVA

Russian Medical Academy of Postgraduate Education

Email: ms_smith@list.ru
Department of Obstetrics and Gynecology Moscow

E. A KHOVRINA

Russian Medical Academy of Postgraduate Education

Department of Obstetrics and Gynecology Moscow

A. S KIRPIKOV

Russian Medical Academy of Postgraduate Education

Department of Obstetrics and Gynecology Moscow

References

  1. Баскаков В.П., Цевелев Ю.В., Кира Е.Ф. Эндометриоидная болезнь. — СПб.: ЭЛБИ, 2002.
  2. Бесплодный брак. Эндометриоз как причина бесплодия. Тактика лечения и ведения пациенток с миомой матки в клинике женского бесплодия / Под ред. B.И. Кулакова. — М.: ГЭОТАР-Медиа, 2005.
  3. Овсянникова Т.В., Ардус Ф.А. Диагностика и лечение бесплодия, обусловленного генитальным эндометриозом // Рос. вестн. акуш.-гин. — 2008. — Т. 8, № 4. — C. 98-100.
  4. Роузви С.К. Гинекология. — М.: МЕДпресс, 2004. — С. 364-380.
  5. Beagley K.W., Gockel C.M. Regulation of innate and adaptive immunity by the female sex hormones estradiol and progesterone // FEMS Immunol. Med. Microbiol. — 2003. — Vol. 38. — P. 13—22.
  6. Beliard A., Noel A., Foidart J.M. Reduction of apoptosis and proliferation in endometriosis // Fertil. and Steril. — 2004. — Vol. 82. — P. 80—85.
  7. Benagiano G., Brosens I. History of adenomyosis // Best Pract. Res. Clin. Obstet. Gynecol. — 2006. — Vol. 20. — P. 449—463.
  8. Bilotas M., Baranao R.I., Buquet R. et al. Effect of GnRH analogues on apoptosis, and expression of Bcl-2, Bax, Fas and Fasl proteins in endometrial epithelial cell cultures from patients with endometriosis and controls // Hum. Reprod. 2007. — Vol. 22. — P. 644—653.
  9. Bourgain C., Ubaldi F., Tavaniotou A. et al. Endometrial hormone rec eptors and proliferation index in the periovulatory phase of stimulated embryo transfer cycles in comparison with natural cycles and relation to clinical pregnancy outcome // Fertil. and Steril. — 2002. — Vol. 78. — P. 237—244.
  10. Busacca M., Somighana E., Bianchi S. et al. Post-operative GnRG analogue treatment after conservative surgery for symphtomatic endometrisis stage III—IV: a randomized controlled trial // Hum. Reprod. — 2001. — Vol. 16, № 11. — P. 2399—2402.
  11. Crosignani P., Olive D., Luciano A. Advances in the management of endometriosis: an apdate of clinicians // Hum. Reprod. Update. — 2006. — Vol. 12. — P. 179—189.
  12. Dmowski W.P., Ding E., Shen J. et al. Apoptosis in endometrial glandular cells in women with and without endometriosis // Hum. Reprod. 2001. — Vol. 16. — P. 1802—1808.
  13. Donnez J., Chantrein F., Nisolle M. The efficacy of medical and surgical treatment of endometriosis-associated infertility: arguments in favour of a medico-surgical approach // Hum. Reprod. Update. — 2002. — Vol. 8. — P. 89—94.
  14. Flores I., Rivera E., Ruiz L.A. et al. Molecular profiling of experimental endometriosis identified gene expression patterns in common with human disease // Fertil. and Steril. — 2007. — Vol. 87, № 5. — P. 1180—1199.
  15. Garry R. Diagnosis of endometriosis and pelvic pain // Fertil. and Steril. — 2006. — Vol. 86. — P. 1307—1309.
  16. Giudice L.C., Kao L.C. Endometriosis // Lancet. — 2004. — Vol. 364. — P. 1789—1799.
  17. Hirota Y., Osuga Y., Hirata T. et al. Possible involvement of thrombin/protease-activated receptor I system in the pathogenesis of endometriosis // J. Clin. Endocrinol. Metab. — 2005. — Vol. 90. — P. 3673—3679.
  18. Hirota Y., Osuga Y., Koga K. et al. Possible implication of midkine in the development of endometriosis // Hum. Reprod. — 2005. — Vol. 20. — P. 1084—1089.
  19. Hirota Y., Osuga Y., Nose E. et al. The presence of midkine and its possible implication in human ovarian follicles // Am. J. Reprod. Immunol. — 2007. — Vol. 58. — P. 367—373.
  20. Ishihara H., Kitawaki J., Kado N. et al. Gonadotropin-releasing hormone agonist and danazol normalize aromatase cytochrome P450 expression in eutopic endometrium from women with endometriosis, adenomyosis or leyomyomas // Fertil. and Steril. — 2003. — Vol. 79. — P. 735—742.
  21. Kalinka J., Szecers-Bartho J. The impact of dydrogesterone supplementation on hormonal profile and progesterone-induced blocking factor concentration in women with threatened abortion // Am. J. Reprod. Immunol. — 2005. — Vol. 53. — P. 1—6.
  22. Khan K.N., Masuzaki H., Fujishita A. et al. Differential macrophage infiltration in early and advanced endometriosis and adjacent peritoneum // Fertil. and Steril. — 2004. — Vol. 81. — P. 652—661.
  23. Khan K.N., Kitajima M., Hiraki K. et al. Immunopathogenesis of pelvic endometriosis: role of hepatocyte growth factor macrophages and ovarian steroids // Am. J. Reprod. Immunol. — 2008. — Vol. 60. — P. 383—404.
  24. Khan K.N., Kitajima M., Hiraki K. et al. Toll-like receptors in innate immunity: role of bacterial endotoxin and toll-like receptor 4 (TLR4) in endometrium and endometriosis // Gynecol. Obstet. Invest. — 2009. Vol. 68. — P. 40—52.
  25. Khan K.N., Kitajama M., Hiraki K. et al. Cell proliferation effect of GnRH agonist on pathological lesions of women with endometriosis, adenomyosis and uterine myoma // Hum. Reprod. — 2010. — Vol. 25, № 11. — P. 2878 — 2890.
  26. Kitajima M., Khan K.N., Fujishita A. et al. Expression of the arylhydrocarbon receptor in the peri-implantation period of the mouse uterus and the impact of dioxin on mouse implantation // Arch. Histol. Cytol. — 2004. — Vol. 67. — P. 465—474.
  27. Kitajima M., Khan K.N., Fujishita A. et al. Histomorphometric alteration and cell-type specific modulation of arylhydrocarbon receptor and estrogen receptor expression by 2,3,7,8-tetrachlorodibemzo-p-dioxin and 17b-estradiol in mouse experimental model of endometriosis // Reprod. Toxicol. — 2004. Vol. 18. — P. 793 —801.
  28. Kyama C.M., Debrock S., Mwenda J.M., DHooghe T.M. Potential involvement of the immune system in the development of endometriosis // Reprod. Biol. Endocrinol. — 2003. — Vol. 1. — P. 123.
  29. Lebovic D.I., Mueller M.D., Taylor R.N. Immunobiology of endometriosis // Fertil. and Steril. — 2001. — Vol. 75. — P. 1—10.
  30. Meresman G.F., Bilotas M.A., Lombardi E. et al. Effect of GnRH analogues on apoptosis and release of interleukin-1ß and vascular endothelial growth factor in endometrial cell cultures from patients with endometriosis // Hum. Reprod. — 2003. — Vol. 18, № 9. — P. 1667—1771.
  31. Ota H., Rong H., Igarashi S., Tanaka T. Suppression of natural kill cell activity by splenocyte transplantation in a rat model of endometriosis // Hum. Reprod. — 2002. — Vol. 17, № 6. — P. 1453 — 1458.
  32. Raghupathy R., Al Mutawa E., Makhseed M. et al. Modulation of cytokine production by dydrogesterone in lymphocytes from women with recurrent miscarriage // Br. J. Obstet. Gynaecol. — 2005. — Vol. 112. — P. 1—6.
  33. Rice V.M. Conventional medical therapies for endometriosis // Ann. N.Y. Acad. Sci. — 2002. — Vol. 955. — P. 343—352.
  34. Tesone M., Bilotas M., Baranao R.I., Meresman G. The role of GnRH analogues in endometriosis-associated apoptosis and angiogenesis // Gynecol. Obstet. Invest. — 2008. — Vol. 66. — P. 10—18.
  35. Vicino M., Scioscia M., Resta L. et al. Fibrotic tissue in the endometrioma capsule: surgical and physiopathologic considerations from histologic findings // Fertil. and Steril. — 2009. — Vol. 91, № 4 (suppl). — P. 1326 —1328.
  36. Walch K., Hefler L., Nagele F. Oral dydrogesterone treatment during the first trimester of pregnancy: the prevention of miscarriage study (PROMIS). A doubleblind, prospectively randomized, placebo-controlled, parallel group trial // J. Matern. Fetal Neonatal Med. — 2005. Vol. 18. — P. 265—269.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies