THE CONTENT OF MAIN SUBPOPULATIONS OF IMMUNOCOMPETENT CELLS IN PREGNANT WOMEN WITH MISCARRIAGE AND ANTIPHOSPHOLIPID SYNDROME DURING INTRAVENOUS IMMUNOGLOBULIN TREATMENT
- Authors: CHUGUNOVA A.A1, ZAINULINA M.S2, SELYUTIN A.V2, SOKOLOV D.I2, MIKHAILOVA V.A2, CHEPANOV S.V2, SELKOV S.A2
-
Affiliations:
- Acad. I.P. Pavlov Saint Petersburg State Medical University
- D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch, Russian Academy of Medical Sciences
- Issue: No 2 (2012)
- Pages: 30-35
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246675
- ID: 246675
Cite item
Open Access
Access granted
Abstract
Objective. To estimate immunological parameters and the course of pregnancy in women with miscarriage in the presence of antiphospholipid syndrome (APS) in the treatment with intravenous immunoglobulin (IVIG) preparations. Subjects and methods. Seventy-three pregnant women with miscarriage and APS, 48 women of whom received an IVIG preparation, were examined. The impact of therapy on the frequency of pregnancy complications and immunological blood was studied. Results. A reduction was found in the frequency of pregnancy complications; moreover, the ratios of lymphocyte subpopulations changed in pregnant women. The use of IVIG preparations contributes to the normalized balance of immunocompetent cells, specifically results in an increase in the level of regulatory T lymphocytes. Conclusion. The use of IVIGs favors the improvement of gestational parameters in women with miscarriage in the presence of APS, which may be mediated by their effect on the activity of regulatory lymphocyte subpopulations.
Full Text
About the authors
A. A CHUGUNOVA
Acad. I.P. Pavlov Saint Petersburg State Medical University
Email: ezericshe@mail.ru
Department of Obstetrics and Gynecology Saint Petersburg
M. S ZAINULINA
D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch, Russian Academy of Medical SciencesSaint Petersburg
A. V SELYUTIN
D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch, Russian Academy of Medical SciencesSaint Petersburg
D. I SOKOLOV
D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch, Russian Academy of Medical SciencesSaint Petersburg
V. A MIKHAILOVA
D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch, Russian Academy of Medical SciencesSaint Petersburg
S. V CHEPANOV
D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch, Russian Academy of Medical SciencesSaint Petersburg
S. A SELKOV
D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch, Russian Academy of Medical SciencesSaint Petersburg
References
- Сельков С.А., Селютин А.В. Методы определения содержания Т-регуляторных клеток в периферической крови // Лаб. диагн. - 2008. - № 4. - С. 19-21.
- Сельков С.А., Селютин А.В., Аржанова О.Н. и др. Роль цитокинов в контроле развития плаценты в норме и при гестозе // Иммунология. - 2009. - № 1. - С. 22-27.
- Сидельникова В.М. Привычная потеря беременности. -М.: Триада-Х, 2005.
- Ярилин А.А., Донецкова Ф.Д. Регуляторные Т-клетки, зависимые от фактора FOXp3, и перспективы их изучения при беременности // Rus. J. Immunol. - 2005. -Т. 9. - С. 149-152.
- Carp H.J., Sapir T., Shoenfeld Y. Intravenous immunoglobulin and recurrent pregnancy loss // Clin. Rev. Allergy Immunol. -2005. - Vol. 29, № 3. - P. 327-332.
- Chen M.L., Pittet M.J., Gorelik L. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-ß signals in vivo // Proc. Natl. Acad. Sci. USA. - 2005. - Vol. 102. - P. 419-424.
- Christiansen O.B., Pedersen B., Rosgaard A., Husth M. A randomized, double-blind, placebo-controlled trial of intravenous immunoglobulin in the prevention of recurrent miscarriage: evidence for a therapeutic effect in women with secondary recurrent miscarriage // Hum. Reprod. - 2002. -Vol. 17. - P. 809-816.
- Coulam C.D., Roussev R.G. Correlation ofNK cell activation and inhibition markers with NK cytoxicity among women experiencing immunologic implantation failure after in vitro fertilization and embryo transfer // J. Assist. Reprod. Genet. - 2003. - Vol. 20. - P. 58-62.
- Guerin L.R., Prins J.R., Robertson S.A. Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment? // Hum. Reprod. Update. - 2009. - Vol. 15, № 5. - P. 517-535.
- Hutton B., Sharma R., Fergusson D. et al. Use of intravenous immunoglobulin for treatment of recurrent miscarriage: a systematic review // Br. J. Obstet.Gynaecol. - 2007. -Vol. 114, № 2. - P. 134-142.
- Lambrianides A., Carroll C.J., Pierangeli S.S. et al. Effects of polyclonal IgG derived from patients with different clinical types of the antiphospholipid syndrome on monocyte signaling pathways // J. Immunol. - 2010. - Vol. 184, № 12. - P. 6622-6628.
- Shoenfeld Y., Katz U. IVIg therapy in autoimmunity and related disorders: our experience with a large cohort of patients // Autoimmunity. - 2005. - Vol. 38, № 2. -P. 123-137.
- Stephenson M., Kutten W.H., Purkiss S. et al. Intravenous immunoglobulin and idiopathic secondary recurrent miscarriage: a multicentered randomized placebocontrolled trial // Hum. Reprod. - 2010. - Vol. 25, № 9. -P. 2203-2209.
- Triolo G., Ferrante A., Accardo-Palumbo A. et al. IVIG in APS pregnancy // Lupus. - 2004. - Vol. 13, № 9. -P. 731-735.
- Trzonkowski P., Szmit E., Mysliwska J. CD4+CD25 + T regulatory cells inhibit human cytotoxic activity of CTL and NK cells in humans - impact of immunosensence // Clin. Immunol. - 2006. - Vol. 119. - P. 307-316.
Supplementary files
