ABNORMAL PREGRAVID UTERINE BLOOD FLOW IN PATIENTS WITH A HISTORY OF PRETERM BIRTH


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Objective. To reveal the specific features of uterine circulation in patients with a history of preterm birth and their relationships to the concomitant factors favoring the development of endothelial dysfunction. Subjects and methods. The study covered 204 patients with a history of preterm birth who were planning their subsequent pregnancy. In addition to preterm birth, 128 of them had complicated last pregnancy, including fetal growth retardation, gestosis, placental abruption, and antenatal fetal death. Clinical and laboratory studies were conducted in all the patients and revealed hereditary hemostatic defects. Uterine artery blood flow was examined by transvaginal scanning on days 7-8 after ovulation. Results. Uterine circulatory disorders (UCD) were found in 40% of the patients with a history of preterm birth and in 8.3% of the control patients. There was an association between the uterine circulation, the time of the manifestations of and nature of gestational complications accompanying a previous pregnancy, the periods of delivery, the blood coagulation system, the diseases contributing to the development of endothelial dysfunction, and the number of years elapsed since labor. Conclusion. Late postgravid UCD in patients with a history of obstetric diseases points to the fact that gestational complications may recur in subsequent pregnancies. Therefore such patients need their uterine system to be rehabilitated before planning their further pregnancy.

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作者简介

G. SAVELYEVA

N.I. Pirogov Russian National Research Medical University

Department of Obstetrics and Gynecology, Faculty of Pediatrics Moscow

E. BUGERENKO

Center for Family Planning and Reproduction, Moscow Healthcare Department

Email: jeddit@yandex.ru
Moscow

O. PANINA

Moscow State University

Department of Obstetrics and Gynecology, Faculty of Fundamental Medicine Moscow

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