PHYTOESTROGENS: WHAT IS KNOWN TODAY


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Abstract

As shown by different authors, 50-85% of women have hot flushes as the most common symptom of the climacteric syndrome (CS). Hot flushes are considered to be a manifestation of peculiar abstinence of the estrogen-sensitive neuronal systems that have been long exposed to high sex hormone levels, and that of their impaired adaptation to the new conditions of estrogen deficiency. CS is a classical indication for traditional hormonal therapy (HT) using natural estrogens or their analogues. However, there are contraindications and limitations of the use of HT due to the risk of endometrial and breast abnormalities in some patients and to its poor impact on the thrombogenic potential of blood. In this connection, a premium is placed upon alternative CS correction methods that include primarily phytopreparations. Isoflavone- containing drugs are much used as an alternative to HT for the treatment of hot flushes, but the documentary information supporting their efficacy is scarce now. It is likely that herbal preparations must have their clear indications and occupy a place in the treatment of menopausal disorders, including CS. Many aspects of the molecular mechanisms of action of herbal extracts are as yet unclear and call for further investigations to assess the risk from the long-term use of phytoestrogens.

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About the authors

I. V RAFAELYAN

I.M. Sechenov First Moscow State Medical University

Email: rafaeirina@yandex.ru

V. E BALAN

I.M. Sechenov First Moscow State Medical University

L. A KOVALEVA

I.M. Sechenov First Moscow State Medical University

Department of Obstetrics, Gynecology, Perinatology, and Reproductology

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