SIGNIFICANCE OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE 1 GENE (SERPINE1: 5G>4G) POLYMORPHISM IN CHORIONIC DETACHMENT AND PLACENTAL ABRUPTION IN EARLY PREGNANCY

Objective. To estimate the significance of allelic variants of SERPINE1 (PAI-1) gene polymorphism in chorionic detachment and placental abruption in early pregnancy. Subjects and methods. A study group consisted of 67 women with recurrent miscarriage in early pregnancy. A control group included 53 healthy primigravidas. SERPINE1: 5G>4G gene polymorphism was determined using the method of adjacent probes with commercial test systems (OOO «NPO DNK-Tekhnologiya», Russia). Ultrasound study was made employing a 512-channel digital scanner (Siemens SonoLine Elegra, Germany). Results. The average detection time for retrochorial and retroamniotic hematomas was 8.3±0.4 and 12.1±0.5 weeks, respectively. Premature detachment of the chorion and placenta was shown to be associated with the number of 4G alleles of the SERPINE1 (PAI-1) gene in the genotype of a patient. In the 4G/4G genotype, the detachments are 1.5 times more common than those in the 5G/4G genotype. The use of selective antifibrinolytics in combination with antiaggregants and/or low-molecular-weight heparins improves pregnancy outcomes. Conclusion. The 4G allele of the SERPINE1 (PAI-1) gene polymorphism is associated with the development of chorionic and placental detachments in early pregnancy. Moreover, in the 4G/4G genotype, the detachments are 1.5 times more frequently encountered than those in the 5G/4G genotype.

early pregnancy periods, plasminogen activator inhibitor type 1, chorionic detachment