TOPICAL USE OF MICRONIZED PROGESTERONE IN REPRODUCTIVE-AGE PATIENTS WITH MASTOPATHY

Objective. To study of the effect of micronized progesterone on the clinical manifestations of mastopathy, the biometric characteristics of the parenchyma, and the rate of breast circulation. Subjects and methods. Micronized progesterone as skin applications was used to treat mastopathy in 42 patients. For the objective characterization of the intensity of pain syndrome, the authors employed the incidence of mastopathy, its mean duration, the nature of pain (distending, aching pain, a sensation of heaviness, exercise-induced pain syndrome; the intensity of mastalgia according to the visual analog scale: mild with a 1-to-3-cm section; moderate, from 4 to 7 cm; severe, from 7 cm or more). Follow-up monitoring of the clin ical picture of the disease, Doppler ultrasound parameters of resistance to blood flow in the breast parenchymal arteries was made before and 3 and 6 months after the initiation of therapy. Results. With the use of micronized progesterone, the rate of mastalgia decreased 2.5- and 3-fold (from 100 to 36% and from 36 to 12%) following 3 and 6 months, respectively. After 6 months of therapy, the thickness of the glandular layer was reduced to 10.78±0.47 mm, which was 1.3 mm time less than that after 3-month therapy (p<0.05). Following 3-month therapy, there were increases in the pulsatility index (PI) by 1.8 times (from 0. 80 to 1. 44%; p<0.001) and resistivity index (RI) by 1.6 times (from 0.46 to 0.76; p<0.001). Following 6 months, there were significant 2-fold increases in PI (from 0.80 to 1.64; p<0.001) and RI (from 0.46 to 0.90; p<0.001), and a 1.5-fold rise in the systolic/diastolic ratio (from 2.89 to 4.39; p<0.05). Conclusion. The use of micronizedprogesterone in patients with mastopathy causes reductions in the duration, intensity, and nature of mastalgia, a change in biometric (decreases in the thickness of the parenchyma, the number of cysts, and the diameter of lactiferous ducts) and functional (hemodynamic) characteristics of the breast.

breast, mastopathy (fibrocystic disease), progesterone