PROGNOSTIC VALUE OF PLACENTAL GROWTH FACTOR IN REDUCING THE FUNCTIONAL ACTIVITY OF A FORMING CHORION IN PREGNANT WOMEN WITH METABOLIC SYNDROME

Objective. To establish a relationship of serum placental growth factor levels in the early gestational period (at 8—9 weeks) in pregnant women with metabolic syndrome (MS) to the clinical picture of preeclampsia and placental insufficiency (PI) and to placental morphological features. Subjects and methods. Eighty-nine pregnant women with MS (Group 1) were examined. A control group consisted of 25 healthy pregnant women (Group 2). Serum human placental grow factor levels (PlGF, pg/ml) were measured and placentas were morphologically studied in all the patients. Results. In the pregnant women with MS, the level of PlGF was ascertained to be slightly lower than that in the control group (р<0.01). The critical level of PlGF in the prognosis of development of PI is its value below 100 pg/ ml. A morphological study of placentas from the puerperas with metabolic syndrome suggests that placental immaturity is much more common with the low level of PlGF. Conclusion. The low level of PlGF may be used as a prognostic criterion for the development of PI and preeclampsia. The lower level of PlGF is in the f irst trimester of pregnancy, the earlier a package of measures should be launched to prevent severe gestational complications.

metabolic syndrome, pregnancy, placental growth factor, placental insuff iciency, preeclampsia