LEVELS OF ACTIVIN A IN THE BLOOD OF SPONTANEOUS ECTOPIC PREGNANCY
- Authors: BURLEV V.A1, ILYASOVA N.A1, PAVLOVITCH S.V1, RASULOVA S.M1
-
Affiliations:
- Academican V.I.Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health and Social Development of Russia
- Issue: No 8-1 (2012)
- Pages: 25-31
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246824
- ID: 246824
Cite item
Abstract
Objective. Comparative the level of activin A in blood at patients with ectopic pregnancy and uteri pregnancy taking into account features of development cytotrophoblast till 7 weeks gestation. Subjects and methods. 38 patients of reproductive age are included in research from 18 till 42 years (30,8±5,3 year). The group of patients with trumpet pregnancy till 7 weeks гестации was made by 16 women, with trumpet pregnancy after 7 weeks - 5 women. Patients with маточной pregnancy: till 7 weeks — 12 women, after 7 weeks — 5. Level of β-hCG in blood serum was carried out immune fluorescent method, progesterone and activin A levels was detection with enzymoimmunoassay. Results. The level of activin A in the blood at spontaneous ectopic pregnancy till 7 weeks does not significant from uteri pregnancy. After 7 weeks level of activin A statistically significant was more low at ectopic pregnancy. Conclusion. The level of activin A in the blood at spontaneous uteri pregnancy should be used for processes cytotrophoblast invasion and placentation at dynamic supervision after 7 weeks gestation.
Keywords
Full Text
About the authors
V. A BURLEV
Academican V.I.Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health and Social Development of Russia
Email: vbourlev@mail.ru
N. A ILYASOVA
Academican V.I.Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health and Social Development of Russia
S. V PAVLOVITCH
Academican V.I.Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health and Social Development of Russia
Sh. M RASULOVA
Academican V.I.Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health and Social Development of Russia
References
- Серова О.Ф., Кириченко А.К., Ермаченко Л.В., Зароченцева Н.В., Добровольская Т.Б. Внематочная беременность: современные аспекты этиологии патогенеза. Российский вестник акушера-гинеколога. 2006; 2: 19-22.
- Atkinson A.J., Colburn W.A., DeGruttola V.G. et al.; Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin. Pharmacol. Ther. 2001; 69(3): 89-95.
- Barnhart K., Van Mello N.M., Bourne T., Kirk E., Van Calster B., Bottomley C. et al. Pregnancy of unknown location: a consensus statement of nomenclature, definitions, and outcome. Fertil. Steril. 2011; 95(3): 857-66.
- Bearfield C., Jauniaux E., Groome N., Sargent I.L., Muttukrishna S. The secretion and effect of inhibin A, activin A and follistatin on first-trimester trophoblasts in vitro. Eur. J. Endocrinol. 2005; 152(6): 909-16.
- Castellucci M., Kosanke G., Verdenelli F., Huppertz B., Kaufmann P. Villous sprouting: fundamental mechanisms of human placental development. Hum. Reprod. Update. 2000; 6(5): 485-94.
- Farquharson R.G., Jauniaux E., Exalto N. Updated and revised nomenclature for description of early pregnancy events. Hum. Reprod. 2005; 11(20): 3008-11.
- Florio P., Luisi S., Ciarmela P., Severi F.M., Bocchi C., Petraglia F. Inhibins and activins in pregnancy. Mol. Cell. Endocrinol. 2004; 225(1-2): 93-100.
- Florio P., Severi F.M., Bocchi C., Luisi S., Mazzini M., Danero S. et al. Single serum activin A testing to predict ectopic pregnancy. J. Clin. Endocrinol. Metab. 2007; 92(5): 1748-53.
- Fowler P.A., Evans L.W., Groome N.P., Templeton A., Knight P.G. A longitudinal study of maternal serum inhibin-A, inhibin-B, activin-A, activin-AB, pro-aC and follistatin during pregnancy. Hum. Reprod. 1998; 13(12): 3530-6.
- Kirk E., Papageorghiou A.T., Van Calster B., Condous G., Cowans N., Van Huffel S. et al. The use of serum inhibin A and activin A levels in predicting the outcome of “pregnancies of unknown location”. Hum. Reprod. 2009; 24(10): 2451-6.
- Kriebs J.M., Fahey J.O. Ectopic pregnancy. J. Midwifery Womens Health. 2006; 51(6): 431-9.
- Muttukrishna S., Jauniaux E., McGarrigle H., Groome N., Rodeck C.H. In-vivo concentrations of inhibins, activin A and follistatin in human early pregnancy. Reprod. BioMed. Online. 2004; 8(6): 712-9.
- Mukul L.V., Teal S.B. Current management of ectopic pregnancy. Obstet. Gynecol. Clin. N. Am. 2007; 34(3): 403-19.
- Shaw J.L.V., Horne A.W. The paracrinology of tubal ectopic pregnancy. Mol. Cell. Endocrinol. 2012; 358(2): 216-22.
- Sowter M.C., Farquhar C.M. Ectopic pregnancy: an update. Curr. Opin. Obstet. Gynecol. 2004; 16: 289-93.
- Qu J., Thomas K. Advance in the study of inhibin, activin and follistatin production in pregnant women. Eur. J. Obstet. Gynecol. Reprod. Biol. 1998; 81: 141-8.
- Warrick J., Gronowski A., Moffett C., Zhao Q., Bishop E., Woodworth A. Serum activin A does not predict ectopic pregnancy as a single measurement test, alone or as part of a multimarker panel including progesterone and hCG. Clin. Chim. Acta. 2012; 413(7-8): 707-11.