THE TIME COURSE OF CHANGES IN THE CLINICAL SYMPTOMS OF ANTIOXIDANDT DEFICIENCY AND ITS CORRECTION WITH THE HERBAL AGENT MASTODYNON IN WOMEN WITH DIFFUSE MASTOPATHY (BENIGN BREAST DISEASE)

Objective. To establish the nature of changes in the parameters of lipid peroxidation and antioxidant defense system and to estimate the alterations of mastalgia when using the herbal agent mastodynon in patients with diffuse mastopathy (benign breast disease). Subjects and methods. The prospective, non-randomized, parallel-group comparative trial enrolled 43 patients (mean age 38.83±1.85 years) with diffuse mastopathy; 30 of them received the herbal medicine mastodynon for 3 months (a study group), 13 patients formed a control group. The intensity of mastalgia was recorded using a visual analog scale and the serum levels of lipid peroxidation products and antioxidants were estimated at baseline and 3 months after therapy. Results. The study group, unlike the control one, showed a significant reduction in the incidence of severe mastalgia, a decrease in the serum levels of lipid peroxidation products, an increase in total antioxidant activity, and a decline in oxidized/reduced glutathione ratio. Conclusion. The trial has demonstrated the antioxidant properties of the herbal agent mastodynon, which can, along with other mechanisms, determine its clinical efficacy in diffuse mastopathy and call for further investigation.

mastopathy, benign breast disease, mastalgia, lipid peroxidation, antioxidants, phytotherapy