EXPERIENCE IN USING GONADOTROPIN-RELEASING HORMONE AGONISTS IN PATIENTS WITH MULTIPLE LEIMYOMATOUS HAMARTOMA OF THE LUNG (A clinical observation)
- Authors: KAYUKOVA S.I1, KOGAN E.A2, CHERNUKHA G.E2, FAIZULLINA N.M2
-
Affiliations:
- Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences
- Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
- Issue: No 8-1 (2012)
- Pages: 74-77
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246850
- ID: 246850
Cite item
Open Access
Access granted
Abstract
The paper describes a rare case of multiple leiomyomatous hamartoma of the lung developed in a perimenopausal patient, the incidence of which is 1—2 cases per 1 million women. A relationship has been found between the progression of leiomyomatous hamartoma of the lung and the high expression of estrogen and progesterone receptors. Since the morphological structure of the described tumor-like process in the lung is similar to that of uterine leiomyoma, the authors have chosen empirically optimal drug therapy regimens. The highest efficiency has been shown by gonadotropin-releasing hormone agonists, whose use relieved clinical symptoms, showed positive X-ray tomographic changes, and stabilized the pulmonary process.
Full Text
About the authors
S. I KAYUKOVA
Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences
Email: kajukova-69@mail.ru
E. A KOGAN
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
Email: evgeniyakogan@gmail.com
G. E CHERNUKHA
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
Email: C-galina@yandex.ru
N. M FAIZULLINA
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia
Email: nafisa05@inbox.ru
References
- Адамян А.А., Халилов А.З., Кудайбергенова И.О. Множественные гамартомы легкого. Вопросы онкологии. 1989;34(2): 227-9.
- Васильев Н.В., Самцов Е.Н., Байдала П.Г. Гамартома легких: предмет исследования и опыт наблюдения. Сибирский онкологический журнал. 2008; 3 (27): 77-81.
- Каменева М.Ю., Двораковская Л.Н., Новикова Л.Н., Баранова О.П., Илькович М.М. Лейомиоматоз легких (морфо-функциональное исследование). Болезни органов дыхания. 2007; 1: 86-95.
- Ерохин В.В., Романова Л.К., ред. Клеточная биология легких в норме и при патологии. М.: Медицина; 2000: 467-74.
- Коган Е.А., Михайлов О.И., Семакова С.М., Корнев Б.М., Осипова И.Н., Осипенко В.И., Романова Н.А., Мухин Н.А. Сочетание лимфангиолейомиоматоза легких, лейомиоматоза кожи и лейомиомы матки. Архив патологии. 2001; 6: 39-44.
- Овчаренко С.И., Сон Е.А. Лимфангиолейомиоматоз -болезнь, поражающая женщин. Пульмонология. 2010; 1: 1-8.
- Самойлова Т.Е. Неоперативные методы лечения миомы матки. Лечащий врач. 2010; 3: 33-7.
- Цветкова О.А., Вашавский В.Н., Рогова Е.Ф., Фоминых Е.В., Буянова О.Е., Колосова К.Ю., Минаева О.Н. Клиническое наблюдение лимфангиолейомиоматоза у женщины 34 лет. Русский медицинский журнал: Пульмонология. 2010;18(18): 1150-6.
- Martin E. Leiomyomatosis lung lesions: a proposed classification. Am. J. Roentgenol. 1983; 141 (2): 269-72.
- Matsui D., Tatsuguchi A., Valencia G., Yu Z., Bechtle J., Beasley M.B. et al. Extrapulmonary leiomyomatosis: clinicopathologic features in 22 cases. Hum. Pathol. 2000; 31(10): 1242-8.
- Rui J.H., Moss J., Beck G.J., Lee J.C., Brown K.K., Chapman J.T. et al. The NHLBI leiomyomatosis registry: characteristics of 230 patients at enrollment. Am. J. Respir. Crit. Care Med. 2006; 173 (1): 105-11.
- Rein M.S. Advances in uterine leiomyoma research: the progesterone hypothesis Environ. Health Perspect. 2001; 108 (Suppl. 5): 791-3.
- Strauss III J.K. Cell biology. In: Bart C.J.M. Fauser, ed. Reproductive medicine: molecular, cellular and genetic fundamentals. Parthenon Publishing; 2003: 55-196.
Supplementary files
