MALE INFERTILITY ASSOCIATED WITH MUTATION AT THE AZF LOCUS OF THE Y CHROMOSOME: CURRENT ASPECTS


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Abstract

The review gives a literature update on different aspects of male infertility associated with mutation at the AZF locus of the Y chromosome. The prevalence of this mutation is estimated in various populations. The outcomes of assisted reproductive technology programs are analyzed in married couples with Y chromosome deletions in husbands. The data of investigations whose objective was to assess an association between mutation at the AZL locus of the Y chromosome and spontaneous miscarriage are given. Whether preimplantation genetic diagnosis may be used as a measure to prevent birth of babies with genetic defects in this category of patients is considered.

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About the authors

A. Anatol'evna BELYAEVA

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: n_belyaeva@oparina4.ru

Zh. I GLINKINA

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: z_glinkina@oparina4.ru

E. A KALININA

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: e_kalinina@oparina4.ru

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