PULMANORY HYPERTENSION AND PREGNANCY: STATUS UPDATE ON THE PROBLEM


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Abstract

Pulmonary hypertension (PH) is a syndrome that is caused of blood restriction through pulmonary arterial system. That leads to increased resistance in blood vessels of the lungs and, by the end, to the right-ventricular dysfunction. Epidemiological studies data showed that prevalence of PH is 15 cases per million populations. Annual mortality among patients who started therapy is 15%. Pregnancy is contraindicated for women with any form of PH because of increased risk of fatality outcomes. Sterilization, contraception and termination of pregnancy are recommended for reproductive age women with PH. At the same time, the experience of these cases management are gathered for women who didn't terminate their pregnancies or if the disease was diagnosed in the last stage of pregnancy. The article presents the data on physiological changes during different stages of gestation and in the postpartum period and its influence on hemodynamic in pregnant women with PH. It also presents risk factors for adverse outcomes development. International experience on management of these patients during pregnancy, delivery and postpartum period is summarized.

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About the authors

N. K RUNIKHINA

V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Email: n_runihina@oparina4.ru
Moscow, Russia

E. A USHAKOVA

V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Moscow, Russia

I. M NOVIKOVA

V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Moscow, Russia

A. V VASILEVA

V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation

Moscow, Russia

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