IMPACT OF HEREDITARY AND ACQUIRED THROMBOPHILIAS ON THE OUTCOME OF ASSISTED REPRODUCTIVE TECHNOLOGY PROGRAMS


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The impact of hereditary and acquired thrombophilias on the results of IVF programs has not adequately investigated. Despite numerous trials estimating antiphospholipid antibody levels and genetic markers for thrombophilia in infertile women, there is no consensus of opinion on its role in embryo implantation failure. The data on whether it is expedient to examine hereditary and acquired risk factors for thrombophilia in repeated IVF failures are ambiguous. Possible mechanisms of implantation failure in the presence of thrombophilic gene polymorphisms are considered. The issues of not only thrombotic and non-thrombotic mechanisms of the impact of thrombophilia on reproductive losses are discussed.

Full Text

Restricted Access

About the authors

I. V NASHLETASHVILI

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: irina.nash@gmail.com

E. A KALININA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_kalinina@oparina4.ru

E. A KOGAN

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_kogan@oparina4.ru

A. E DONNIKOV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_donnikov@oparina4.ru

References

  1. Focus on Reproduction. News letter of the European Society of Human Reproduction and Embryology. January, 2011. http://www.eshre.eu
  2. Судома И.А., Маслий Ю.В. Алгоритм обследования и лечения пациентов с многократными неудачными программами ВРТ. В кн.: Репродуктивные технологии сегодня и завтра: Материалы XVII международной конференции. Казань, 6-8 сентября 2007 г. Казань; 2007: 20-1.
  3. Margalioth E.J., Ben-Chetrit A., Gal M., Eldar-Geva T. Investigation and treatment of repeated implantation failure following IVF-ET. Hum. Reprod. 2006; 21(12): 3036-43.
  4. Simon A., Laufer N. Repeated implantation failure: clinical approach. Fertil. Steril. 2012; 97(5): 1039-43.
  5. Лузин А.А., Рудакова Е.Б., Бурова О.М., Пилипенко М.А., Лобода О.А., Полторака Е.В. Влияние патологии эндометрия и нарушений в системе гемостаза на исходы вспомогательных репродуктивных технологий. Вестник Российского университета дружбы народов. 2009; 7: 101-6.
  6. Сароян Т.Т. Особенности течения беременности у женщин с тяжелой формой синдрома гиперстимуляции яичников: Дис.. канд. мед. наук. М.; 2009. 120с.
  7. Сидельникова В.М., Сухих Г.Т. Невынашивание беременности: Руководство для практикующих врачей. М.: МИА; 2010: 225-7.
  8. Ходжаева З.С. Основы профилактики и лечения наследственных тромбофилий. Эффективная фармакотерапия в акушерстве и гинекологии. 2010; 4: 26-31.
  9. Джанжгава Ж.Г. Клиническое значение выявления тромбофилии у пациенток с бесплодием и неудачами ЭКО: Дис.. канд. мед. наук. М.; 2005. 120с.
  10. Coulam C.B., Jeyendran R.S. Thrombophilic gene polymorphisms are risk factors for unexplained infertility. Fertil. Steril. 2009; 91(4, Suppl.): 1516-7.
  11. Wu O., Robertson L., Twaddle S., Lowe G. D., Clark P., Greaves M. et al. Screening for thrombophilia in high-risk situations: systematic review and cost-effectiveness analysis. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study. Health Technol. Assess. 2006; 10(11): 1-110.
  12. Emmerich J., Rosendaal F. R., Cattaneo M., Margaglione M., De Stefano V., Cumming T. et al. Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism--pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. Study Group for Pooled-Analysis in Venous Thromboembolism. Thromb. Haemost. 2001; 86(3): 809-16.
  13. Gohil R., Peck G., Sharma P. The genetics of venous thromboembolism. A meta-analysis involving approximately 120,000 cases and 180,000 controls. Thromb. Haemost. 2009; 102(2): 360-70.
  14. Ridker P.M., Miletich J.P., Hennekens C.H., Buring J.E. Ethnic distribution of factor V Leiden in 4047 men and women. Implications for venous thromboembolism screening. JAMA. 1997; 277(16): 1305-7.
  15. Wilkins-Port C.E., Freytag J., Higgins S.P., Higgins P.J. PAI-1: A multifunctional SERPIN with complex roles in cell signaling and migration. Cell Commun. Insights. 2010; 3: 1—10.
  16. Охтырская Т.А. Оптимизация программы экстракорпорального оплодотворения у пациенток с риском развития тромбофилии: Дис.. канд. мед. наук. М.; 2011. 123с.
  17. Goodman C., Jeyendran R.S., Coulam C.B. P53 tumor suppressor factor, plasminogen activator inhibitor, and vascular endothelial growth factor gene polymorphisms and recurrent implantation failure. Fertil. Steril. 2009; 92(2): 494-8.
  18. Forges T., Monnier-Barbarino P., Alberto J.M., Guéant-Rodriguez R.M., Daval J.L., Guéant J.L. Impact of folate and homocysteine metabolism on human reproductive health. Hum. Reprod. Update. 2007; 13(3): 225-38.
  19. Berker B., Kaya C., Aytac R., Satiroglu H. Homocysteine concentrations in follicular fluid are associated with poor oocyte and embryo qualities in polycystic ovary syndrome patients undergoing assisted reproduction. Hum. Reprod. 2009; 24(9): 2293-302.
  20. Boxmeer J.C., Macklon N.S., Lindemans J., Beckers N.G., Eijkemans M.J., Laven J.S. et al. IVF outcomes are associated with biomarkers of the homocysteine pathway in monofollicular fluid. Hum. Reprod. 2009; 24(5): 1059-66.
  21. Макацария А.Д., Бицадзе В.О., Акиньшина С.В. Тромбозы и тромбоэмболии в акушерско-гинекологической клинике. М.: МИА; 2007. 1064c.
  22. Azem F., Many A., Ben Ami I., Yovel I., Amit A., Lessing J.B., Kupferminc M.J. Increased rates of thrombophilia in women with repeated IVF failures. Hum. Reprod. 2004; 19(2): 368-70.
  23. Grandone E. Infertility and thrombophilia. Thromb. Res. 2005; 115 (Suppl.1): 24-7.
  24. Qublan H., Amarin Z., Dabbas M., Farraj A.E., Beni-Merei Z., Al-Akash H. et al. Low-molecular-weight heparin in the treatment of recurrent IVF-ET failure and thrombophilia: a prospective randomized placebo-controlled trial. Hum. Fertil. (Camb.). 2008; 11(4): 246-53.
  25. Martinelli I., Taioli E., Ragni G., Levi-Setti P., Passamonti S.M., Battaglioli T. et al. Embryo implantation after assisted reproductive procedures and maternal thrombophilia. Haematologica. 2003; 88(7): 789-93.
  26. Vaquero E., Lazzarin N., Caserta D., Valensise H., Baldi M., Moscarini M., Arduini D. Diagnostic evaluation of women experiencing repeated in vitro fertilization failure. Eur. J. Obstet. Gynecol. Reprod. Biol. 2006; 125(1): 79-84.
  27. Gopel W., Ludwig M., Junge A.K., Kohlmann T., Diedrich K., Möller J. Selection pressure for the factor-V-Leiden mutation and embryo implantation. Lancet. 2001; 358(9289): 1238-9.
  28. Rudick B., Su H.I., Sammel M.D., Kovalevsky G., Shaunik A., Barnhart K. Is factor V Leiden mutation a cause of in vitro fertilization failure? Fertil. Steril. 2009; 92(4): 1256-9.
  29. Simur A., Ozdemir S., Acar H., Colakoğlu M.C., Görkemli H., Balci O., Nergis S. Repeated in vitro fertilization failure and its relation with thrombophilia. Gynecol. Obstet. Invest. 2009; 67(2): 109-12.
  30. Nelson S.M., Greer I.A. The potential role of heparin in assisted conception. Hum. Reprod. Update. 2008; 14(6): 623-45.
  31. Джанджгава Ж.Г., Бицадзе В.О. Неудачи ЭКО и материнская тромбофилия. Проблемы репродукции. 2005; 11(5): 41-3.
  32. Бицадзе В.О., Макацария А.Д., Хизроева Д.Х., Макацария Н.А., Яшенина Е.В. Тромбофилия как важнейшее звено патогенеза осложнений беременности. Практическая медицина. 2012; 5(60): 22-9.
  33. Tan В.К., Vandekerckhove P., Kennedy R., Keay S.D. Investigation and current management of recurrent IVF treatment failure in the UK. Br. J. Obstet. Gynaecol. 2005; 112(6): 773-80.
  34. Di Nisio M., Rutjes A.W., Ferrante N., Tiboni G.M., Cuccurullo F., Porreca E. Thrombophilia and outcomes of assisted reproduction technologies: a systematic review and meta-analysis. Blood. 2011 Sep 8;118(10):2670-8.
  35. Nelson S.M. Is placental haemostasis relevant to recurrent implantation failure? Thromb. Res. 2011; 127(Suppl.3): S93-5.
  36. Practice Committee of American Society for Reproductive Medicine. Antiphospholipid antibodies do not affect IVF success. Fertil. Steril. 2008; 90(5,Suppl.): S172—3. ОБЗОРЫ
  37. American Society for Reproductive Immunology Antiphospholipid Antibody Committee. A rational basis for antiphospholipid antibody testing and selective immunotherapy in assisted reproduction: a rebuttal to the American Society for Reproductive Medicine Practice Committiee Opinion. Fertil. Steril. 2000; 74(4): 631-4.
  38. Bohlmann M.K. Effects and effectiveness of heparin in assisted reproduction. J. Reprod. Immunol. 2011; 90(1): 82-90.
  39. Siristatidis C.S., Dodd S.R., Drakeley A.J. Aspirin for in vitro fertilisation. Cochrane Database Syst. Rev. 2011; (8): CD004832.
  40. Bellver J., Soares S.R., Alvarez C., Muñoz E, Ramírez A., Rubio C. et al. The role of thrombophilia and thyroid autoimmunity in unexplained infertility, implantation failure and recurrent spontaneous abortion. Hum Reprod. 2008; 23(2): 278-84.
  41. Kuperman A., Di Micco P., Brenner B. Fertility, infertility and thrombophilia. Womens Health (Lond., Engl.). 2011; 7(5): 545-53.
  42. Masini S., Ticconi C., Gravina P., Tomassini M., Pietropolli A., Forte V. et al. Thrombin-activatable fibrinolysis inhibitor polymorphisms and recurrent pregnancy loss. Fertil. Steril. 2009; 92(2): 694-70.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies