ROLE OF GENETIC FACTORS IN THE DEVELOPMENT OF NEONATAL RESPIRATORY DISORDERS IN PLACENTAL INSUFFICIENCY


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Abstract

Objective. To study the role of gene polymorphism in pregnant women with placental insuff iciency (PI) in the realization of respiratory disorders (RD) in their neonates. Subjects and methods. A prospective study was conducted on 202 patients with PI, by investigating the distribution of alleles and genotypes of polymorphic loci in the mothers and their newborn infants. Results. The mothers with the TT genotype at -251 position of the promotor region of the IL8 gene more often gave birth to babies with further intrauterine infection realization. If the mother had A allele of ESR1 gene polymorphism: -351G>A (XbaI), the baby significantly more frequently developed respiratory distress syndrome (OR=1.85 (1.1-3.2); p=0.029). Conclusion. Our findings allow IL8 and ESR1 gene polymorphisms to be determined in pregnant women with PI as a predictor of RD in their neonates.

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About the authors

N. E KAN

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_kan@oparina4.ru

N. A LOMOVA

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: natasha-lomova@yandex.ru

A. E DONNIKOV

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_donnikov@oparina4.ru

V. V ZUKBOV

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: v_zubkov@oparina4.ru

S. V PAVLOVICH

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: s_pavlovich@oparina4.ru

N. V DUBROVINA

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_dubrovina@oparina4.ru

V. L TYUTYUNNIK

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: v_tutunnik@oparina4.ru

G. T SUKHIKH

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

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