THE CLINICAL AND MOLECULAR GENETIC RISK FACTORS OF PREMATURE RUPTURE OF MEMBRANES IN PREGNANT WOMEN WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA


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Abstract

Objective. To assess the role of gene polymorphisms in structural proteins and that of the system regulating the homeostasis of the connective tissue extracellular matrix in the development of premature amniorrhea (PA). Subjects and methods. The investigation covered 82 parturients with PA (Group 1, a study group), 97 parturients without this condition (Group 2, a comparison group) (179 mother-baby pairs) at 37-41 weeks gestation. Single nucleotide polymorphisms (SNP) associated with impaired connective tissue homeostasis were chosen as potential molecular genetic predictors of PA. Results. Polymorphisms of the maternal MMP9 (C/C genotype: -1562 C>T) and fetal MMP2 (AA genotype: -735 C> A) genes were established, which are responsible for the risk of PA. Conclusion. The risk of PA increases in the presence of polymorphisms of the MMP9 and MMP2 genes for the mother and the fetus, respectively. Impaired connective tissue homeostasis may be a predisposing factor of PA.

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About the authors

N. E KAN

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russian

Email: n_kan@oparina4.ru

M. V SANNIKOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russian

Email: msannikova@yandex.ru

A. E DONNIKOV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russian

Email: a_donnikov@oparina4.ru

I. V KLIMANTSEV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russian

E. YU AMIRASLANOV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russian

Email: e_amiraslanov@oparina4.ru

N. A LOMOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russian

Email: natasha-lomova@yandex.ru

M. I KESOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russian

Email: m_kesova@oparina4.ru

P. A KOSTIN

OOO «Eco-med-cM», Moscow

Email: kostin@ecomeds.ru

V. L TYUTYUNNIK

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russian

Email: tyutyunnik@mail.ru

G. T SUKHIKH

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russian

Email: g_sukhikh@oparina4.ru

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