FEATURES OF COGNITIVE PERFORMANCE IN POSTMENOPAUSAL WOMEN WITH ARTERIAL HYPERTENSION

Objective. To assess cognitive performance in outpatient postmenopausal women with arterial hypertension. Methods. 58 women ages 44 to 88 with arterial hypertension took part in investigations. Clinical investigation, blood chemistries, echocardiographic tests were performed for all of them. 24-hour blood pressure monitoring and treadmill tests were performed in 39 women. Depression and anxiety were assessed by using Hospital Anxiety and Depression Scale in all women and psycho-emotional status were assessed by using Mini-mental State Examination in 49 women. Results. Among women with hypertension during postmenopausal period cognitive dysfunction were revealed in 40, 8%: 24, 8% mild stage, 8, 2% moderate stage and in 6, 1% dementia was developed mild and moderate severity. Decreasing of cognitive status was associated with early menopausal age (р=0,001, r=-0, 77), obesity (р<0,001, r=0, 95), depression (р<0,001, r=-0, 55). Strong correlation was found among systolic blood pressure and severity of cognitive impairment (р<0,001, r=-0, 95). Decrease of left ventricular ejection fraction (р=0,001, OR 0, 22, 95% CI0, 09-0, 52) and left atrial enlargement according to ECHO (р=0,013, OR 11, 6, 95% CI 1, 67-79, 8) was independent risk factors for cognitive status reduction. Cognitive impairment was associated with obesity (р=0,004, OR 0,09, 95% CI 0,02-0,47), hyperlipidemia (р<0,001, OR 0,03, 95% CI 0,01-0,22), elevated blood urea nitrogen (р=0,001, OR 0,06, 95% CI 0,01 0,29) elevated blood glucose level (р=0,012, OR 6,3, 95% CI 1,5-25,9). Conclusion. Decline of cognitive status in women with AH is associated with early age of menopausal onset, obesity, depression, and dysfunctional lipid and carbohydrate metabolisms. Timely diagnosis of cognitive impairment is critical at early stages to maximize the greatest success of therapy.

arterial hypertension, postmenopause, cognitive impairment