THE DEGREE OF MYOMETRIAL STRETCH IS AN IMPORTANT REGULATOR OF UTERINE CONTRACTILE ACTIVITY
- Authors: KOVALEV V.V1,2, TSYVYAN P.B2,3, MILYAEVA N.M2, LUKIN O.N3, PROTSENKO Y.L3
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Affiliations:
- Ural Research Institute of Maternity and Infancy Care, Ministry of Health of Russia
- Ural State Medical Academy, Ministry of Health of Russia
- Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences
- Issue: No 2 (2013)
- Pages: 62-67
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246919
- ID: 246919
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Abstract
Objective. To investigate the impact of stretch on the contractile activity of isolated myometrial specimens from women during pregnancy and non-pregnancy. Material and methods. Isolated myometrial specimens (S) obtained at cesarean section from the women during normal (Group 1) and powerless (Group 2) labor and non-labor (Group 3) were used to study the impact of the mechanical stretch (Str) of the specimens on spontaneous contraction rate, tonic and phasic contraction amplitude, and contractile activity interval. Results. Stepwise Str caused an increase in the rate of spontaneous contractions (C), the amplitude of phasic Cs, and the interval of contractility in all the groups, which was most pronounced in Group 1. With higher Str, the majority of Group 2 specimens showed a considerable abnormality in the relaxation phase of phasic C. Whether stretch-activated TRPC proteins play a role in different myometrial contractility reactions to Str during normal and abnormal labor and non-labor is discussed.
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About the authors
V. V KOVALEV
Ural Research Institute of Maternity and Infancy Care, Ministry of Health of Russia; Ural State Medical Academy, Ministry of Health of Russia
Email: omm-dir@k66.ru
P. B TSYVYAN
Ural State Medical Academy, Ministry of Health of Russia; Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences
Email: Tsyvian@hotbox.ru
N. M MILYAEVA
Ural State Medical Academy, Ministry of Health of Russia
Email: soneta64@rambler.ru
O. N LUKIN
Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences
Email: O.Lukin@iip.uran.ru
Yu. L PROTSENKO
Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences
Email: Y.protsenko@iip.uran.ru
References
- Крицкая И.А. Особенности течения раннего неонатального периода у новорожденных от матерей со слабостью родовой деятельности: Автореф. дис.. канд. мед. наук. М.; 2005.
- Овешникова Т.З. Современные методы коррекции слабости родовой деятельности: Автореф. дис. канд. мед. наук. М.; 2004.
- Подтетенев А.Д., Стрижова Н.В. Аномалии родовой деятельности: Учебное пособие. М.: МИА; 2006.
- Сидорова И.С. Физиология и патология родовой деятельности: Учебное пособие. М.: МИА; 2000.
- Сидорова И.С. Гипертоническая дисфункция сократительной деятельности матки. Вестник Российской ассоциации акушеров-гинекологов. 1998; 1: 98—106.
- Bytantiene E., Vedernikov Y.P., Saade G, Romero R., Garfield R.E. Effect of histamine on phasic and tonic contractions of isolated uterine tissue from pregnant women. Am. J. Obstet. Gynecol. 2003; 188(3): 774-8.
- Calaghan S.C., Belus A., White E. Do stretch-induced changes in intracellular calcium modify the electrical activity of cardiac muscle? Prog. Biophys. Mol. Biol. 2003; 82(1-3): 81-95.
- Challis J.R.G. Mechanism of parturition and preterm labor. Obstet. Gynecol. Surv. 2000; 55(10): 650-60.
- Dalrymple A., Slater D.M., Beech D., Poston L., Tribe R.M. Molecular identification and localization of Trp. homologues, putative calcium channels, in pregnant human uterus. Mol. Hum. Reprod. 2002; 8(7): 946-51.
- Dalrymple A., Mahn K., Poston L., Songu-Mize E., Tribe R.M. Mechanical stretch regulates TRPC expression and calcium entry in human myometrium smooth muscle cells. Mol. Hum. Reprod. 2007; 13(3): 171-9.
- El-Sayed Y.Y., Riley E.T., Holbrook R.H.Jr, Cohen S.E., Chitkara U., Druzin M.L. Randomized comparison of intravenous nitroglycerin and magnesium sulfate for treatment of preterm labor. Obstet. Gynecol. 1999; 93(1): 79-83.
- Hatthachote P., Gillespie J.I. Complex interactions between sex steroids and cytokines in the human pregnant myometrium: evidence for an autocrine signaling system at term. Endocrinology. 1999; 140(6): 2533-40.
- Longo M., Jain V., Vedernikov Y.P., Hankins G.D.V., Garfield R.E., Saade G.R. Effect of L-type Ca2+ channel blockade and K+ channel opening and nitric oxide on human uterine contractility in relation to gestational age and labour. Mol. Hum. Reprod. 2003; 9(3): 159-64.
- Loudon J.A., Sooranna S.R., Bennett P.R., Johnson M.R. Mechanical stretch of human uterine smooth muscle cells increases IL-8 mRNA expression and peptide synthesis. Mol. Hum. Reprod. 2004; 10(12): 895-9.
- Maroto R., Raso A., Wood T.G., Kurosky A., Martinac B., Hamill O.P. TrpC1 forms the stretch-activated cation channel in vertebrate cells. Nat. Cell Biol. 2005; 7(2): 105-7.
- McCarron J.G., Crichton C.A., Langton P.D., MacKenzie A., Smith G.L. Myogenic contraction by modulation of voltage-dependent calcium currents in isolated rat cerebral arteries. J. Physiol. 1997; 498(1): 371-9.
- Phillippe M., Saunders T., Basa A. Intracellular mechanisms underlying prostaglandin stimulated phasic myometrial contractions. Am. J. Physiol. 1997; 273(4,Pt 1): E665-73.
- Sooranna S.R., Lee Y., Kim L.U., Mohan A.R., Bennett P.R., Johnson M.R. Mechanical stretch activates type 2 cyclooxygenase via activator protein-1 transcription factor in human myometrial cells. Mol. Hum. Reprod. 2004; 10(2): 109-13.
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