CLINICAL AND BIOCHEMICAL PREDICTORS FOR THE DEVELOPMENT OF PREECLAMPSIA

Objective. To identify clinical and biochemical predictors for the development of preeclampsia (PE). Subject and methods. The prospective study enrolled 127 pregnant women, including 74 women whose pregnancy was uncomplicated by PE, 50 pregnant women with moderate PE, and 3 patients with severe PE. The course of pregnancy and labor and biochemical blood parameters were analyzed. Results. PE is associated with the high rate of pregnancy pathology. The found correlations between different obstetric complications suggest that they have similar mechanisms of development. Severe PE has been ascertained to be accompanied by higher liver function test values, hyperfibrinogenemia, and lower blood levels of total protein with increased nitrogen metabolic parameters and impaired lipid metabolism and to be associated with an acute-phase reaction. In moderate PE, the above changes are less pronounced. The level of trophoblastic β 1-glycoprotein, a marker of placental insufficiency, in PE, in its severe form in particular, decreases in the second trimester and correlates with the incidence of PE during pregnancy. Conclusion. The most diagnostically significant predictors of severe PE are increased CRP levels in the first trimester and impaired uterine-placental-fetal blood flow, elevated CRP levels, changes in lipid metabolism (hypercholesterolemia) and hemostasis (hyperfibrinogenemia), and reduced trophoblastic β 1-glycoprotein levels in the second trimester.

preeclampsia, biochemical blood parameters, systemic inflammatory response syndrome, hyperlipidemia