PREVENTION OF RECURRENT MISCARRIAGE IN PATIENTS WITH NON-DEVELOPING PREGNANCY DURING CHRONIC ENDOMETRITIS

Objective. To enhance the efficiency of prevention of recurrent miscarriage in patients with non-developing pregnancy in the presence of chronic endometritis. Subject and methods. One hundred and ten patients at weeks 5-12 of non-developing pregnancy were examined. The morphological and immunomorphological features of the endometrium and ovum tissue were investigated; cellular and humoral immunities were evaluated; the content of the vagina, cervical canal, and uterine cavity underwent comprehensive microbiological analysis. Results. Chronic endometritis exacerbation was morphologically verified in 66 (60%) patients. All the patients received a complex of etiotropic anti-inflammatory therapy and treatment aimed at restoring the endometrial morphofunctional potential. The patients with chronic endometritis had basic postoperative therapy (Group 1); in Group 2 (n = 33), combination treatment encompassed a course of enzyme therapy using a long-acting agent with hyaluronidase activity (Longidase). Conclusion. The use of the enzyme agent Longidase in combination rehabilitation therapy allows the rate of recurrent miscarriage to be reduced in patients with chronic endometritis.

non-developing pregnancy, chronic endometritis, enzyme agents