THE DIAGNOSIS, PREVENTION, AND TREATMENT OF BENIGN BACKGROUND DISEASES OF THE CERVIX UTERI IN REPRODUCTIVE-AGED WOMEN LIVING IN AN IODINE-DEFICIENT REGION
- Authors: PODOLSKY V.V1, SHTUL I.A1
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Affiliations:
- Institute of Pediatrics, Obstetrics, and Gynecology, National Academy of Medical Sciences of Ukraine
- Issue: No 5 (2013)
- Pages: 81-86
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246967
- ID: 246967
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Abstract
Objective. To ascertain via what mechanisms for thyroid dysfunction the impact of iodine deficiency on the occurrence and progression of benign tumors of the cervix uteri (CU) is shown. Subjects and methods. 100 fertile-aged women, including 50 women who lived in an iodine-deficient area (Transcarpathian Region) and had benign CU diseases (Group 1 (a study group)) and 50 who resided in a non-iodine-deficient area (Poltava Region) and had no CU pathology (Group 2 (a comparison group)), were examined. Clinical, microbiological, hormonal, and instrumental studies and determination of daily urine iodine excretion the cerium-arsenite method were made. Results. The correlation between ioduria and the serum levels of sex, gonadotropic, and thyroid hormones was analyzed in women with background cervical diseases, who lived in the region with natural iodine deficiency. The specific features of reproductive disorders were shown depending on the nosological entity of background CU diseases. Conclusion. The most marked iodine deficiency was found in CU polyps (100%) and cylindrical epithelial ectopia (93%). In grades I and II goiter, thyroid functional impairments (38%) were presented with subclinical and clinical hypothyroidism, respectively. Diminished pituitary-ovarian function was detected in women with background diseases of CU, which appeared as relative hyperestrogenism and hypoprogesteronemia worsening depending on the degree of iodine deficiency.
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About the authors
V. V PODOLSKY
Institute of Pediatrics, Obstetrics, and Gynecology, National Academy of Medical Sciences of Ukraine
Email: podolskyivv@gmail.com
Kiev
I. A SHTUL
Institute of Pediatrics, Obstetrics, and Gynecology, National Academy of Medical Sciences of Ukraine
Email: dr.stul@mail.ru
Kiev
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