ROLE OF HEREDITARY THROMBOPHILIA IN THE GENESIS OF COMPLICATED PREGNANCY


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Abstract

The literature review shows the role of hereditary thrombophilia in the development of different gestational complications. It gives information on the contribution of individual gene polymorphisms of inherited thrombophilia and their combination (Leiden FV 1691G/A, thrombin FII 20210G/A, MTHFR 677C/T, etc.) to the development of major obstetric complications (recurrent miscarriage, placental insufficiency, fetal growth restriction, placental abruption).

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About the authors

O. M ZARUDSKAYA

Saint Ioasaf Belgorod Regional Clinical Hospital

Email: zarudskayaom@yandex.ru
Belgorod

M. I CHURNOSOV

Belgorod State University

Belgorod

References

  1. Айламазян Э.К., Кулаков В.И., Радзинский В.Е., Савельева Г.М., ред. Акушерство: Национальное руководство. М.: ГЭОТАР-Медиа; 2007. 1200 с.
  2. Макацария А.Д., Бицадзе В.О., Акиньшина С.В. Тромбозы и тромбоэмболии в акушерско-гинекологической клинике: Молекулярно-генетические механизмы и стратегия профилактики тромбоэмболических осложнений: Руководство для врачей. М.: МИА; 2007. 1064 с.
  3. Макацария А.Д, Бицадзе В.О. Тромбофилии и противо-тромботическая терапия в акушерской практике. М.: Триада-X; 2003. 904 с.
  4. Макацария А.Д., Пшеничникова Е.Б., Пшеничникова Т.Б., Бицадзе В.О. Метаболический синдром и тромбофилия в акушерстве и гинекологии. М.: МИА; 2006. 480 с.
  5. Степанова А.А., Дробинская А.Н., Пасман Н.М., Стуров В.Г. Тактика ведения беременных с тромбофилией. Вестник Новосибирского государственного университета. 2009; 7(2): 34—43.
  6. Franchi F., Cetin I., Todros T., Antonazzo. P., Nobile de Santis M.S., Cardaropoli S. et al. Intrauterine growth restriction and genetic predisposition to trombophilia. Haematologica. 2004; 89: 444—9.
  7. Howley H.E., Walker M., Rodger M.A. A systematic review of the association between factor V Leiden or prothrombin gene variant and intrauterine growth restriction. Am. J. Obstet. Gynecol. 2005; 192: 694—708.
  8. Infante-Rivard C., Rivard G.E., Guiguet M., Gauthier R. Thrombophilic polymorphisms and intrauterine growth restriction. Epidemiology. 2005; 16(3): 281—7.
  9. Ivanov P., Komsa-Penkova R., Konova E., Kovacheva K., Ivanov I., Ivanov M. et al. Inherited thrombophilic factors in women with unexplained intrauterine fetal deaths. Akush. Ginekol. (Sofiia). 2009; 48(4): 3—7.
  10. Kovacheva K., Simeonova M., Ivanov P. Inherited thrombophilia and pregnancy with fetal loss. Akush. Ginekol. (Sofiia). 2007; 46(4): 8—14.
  11. Larciprete G., Rossi F., Deaibess T., Brienza L., Barbati G., Romanini E. et al. Double inherited thrombophilias and adverse pregnancy outcomes: fashion or science? J. Obstet. Gynaecol. Res. 2010; 36(5): 996—1002.
  12. Nour M., Slama F.B., Maaroufi R.M., Hammami M., Mahjoub T. Factor VII polymorphisms associated with plasma factor VII coagulant activity levels in healthy Tunisians. East. Mediterr. Health J. 2005; 11(1-2): 102—8.
  13. Rajewski M., Skrzypczak J. Frequency of antiphospholipid antibodies and factor V (G1691A), prothrombin (G20210A) gene polimorphism among women with pregnancy complications. Pol. Arch. Med. Wewn. 2006; 115(5): 417—25.
  14. Raju N., Bates S.M. Preventing thrombophilia-related complications of pregnancy. Expert Rev. Hematol. 2009; 2(2): 183—96.
  15. Said J.M., Tsui R., Borg A.J., Higgins J.R., Moses E.K., Walker S.P. et al. The PAI-1 4G/5G polymorphism is not associated with an increased risk of adverse pregnancy outcome in asymptomatic nulliparous women. J. Thromb. Haemost. 2012; 10(5): 881—6.
  16. Seremak-Mrozikiewicz A., Drews K., Kurzawinska G., Barlik M., Mrozikiewicz P.M. The connection between Arg353Gln polymorphism of coagulation factor VII and recurrent miscarriages. Ginekol. Pol. 2009; 80(1): 8—13.
  17. Shanker J., Perumal G., Maitra A., Rao V.S., Natesha B.K., John S. et al. Genotype-phenotype relationship of F7 R353Q polymorphism and plasma factor VII coagulant activity in Asian Indian families predisposed to coronary artery disease. J. Genet. 2009; 88(3): 291—7.
  18. Silver R.M., Zhao Y., Spong C.Y., Sibai B., Wendel G.Jr., Wenstrom K. et al.; Eunice Kennedy Shriver National Institute of Child health and Human Development Maternal-Fetal Medicine Units (NICHD MFMU) Network. Prothrombin gene G20210A mutation and obstetric complications. Obstet. Gynecol. 2010; 115(1): 14—20.
  19. Carbone J.F., Rampersad R. Prenatal screening for thrombophilias: indications and controversies. Clin. Lab. Med. 2010; 30(3): 747—60.
  20. Stella C.L., Sibai B.M. Thrombophilia and adverse maternal-perinatal outcome. Clin. Obstet. Gynecol. 2006; 49(4): 850—60.
  21. Kosar A., Kasapoglu B., Kalyoncu S., Turan H., Balcik O.S., Gümüs E.I. Treatment of adverse perinatal outcome in inherited thrombophilias: a clinical study. Blood Coagul. Fibrinolysis. 2011; 22(1): 14—8.
  22. Близнецкая С.Л. Основные наследственные тромбофилии и их роль при привычном невынашивании беременности: Автореф. дис.. канд. мед. наук. М.; 2009.
  23. Макацария А.Д., Бицадзе В.О. Тромбофилические состояния в акушерской практике. М.: РУССО; 2001. 704 с.
  24. Anteby E.Y., Musalam B., Milwidsky A., Blumenfeld A., Gilis S., Valsky D. et al. Fetal inherited thrombophilias influence the severity of preeclampsia, IUGR and placental abruption. Eur. J. Obstet. Gynecol. Reprod. Biol. 2004; 113(1): 31—5.
  25. Facco F., You W., Grobman W. Genetic thrombophilias and intrauterine growth restriction: a meta-analysis. Obstet. Gynecol. 2009; 113(6): 1206—16.
  26. Verspyck E., Borg J.Y., Le Cam-Duchez V., Goffinet F., Degre S., Fournet P. et al. Thrombophilia and fetal growth restriction. Eur. J. Obstet. Gynecol. Reprod. Biol. 2004; 113(1): 36—40.
  27. Jamal A., Hantoshzadeh S., Hekmat H., Abbasi S. The association of thrombophilia with fetal growth restriction. Arch. Iran Med. 2010; 13(6): 482-5.
  28. Simchen M.J., Ofir K., Moran O., Kedem A., Sivan E., Schiff E. Thrombophilic risk factors for placental stillbirth. Eur. J. Obstet. Gynecol. Reprod. Biol. 2010; 153(2): 160—4.
  29. Said J.M., Higgins J.R., Moses E.K., Walker S.P., Monagle P.T., Brennecke S.P. Inherited thrombophilias and adverse pregnancy outcomes: a case-control study in an Australian population. Acta Obstet. Gynecol. Scand. 2012; 91(2): 250—5.
  30. Procházka M., Lubuský M., Slavík L., Hrachovec P., Zielina P., Kudela M. et al. Frequency of selected thrombophilias in women with placental abruption. Aust. N. Z. J. Obstet. Gynaecol. 2007; 47(4): 297—301.
  31. Karakantza M., Androutsopoulos G., Mougiou A., Sakellaropoulos G., Kourounis G., Decavalas G. Inheritance and perinatal consequences of inherited thrombophilia in Greece. Int. J. Gynaecol. Obstet. 2008; 100(2): 124—9.
  32. Kinzler W.L., Prasad V., Ananth C.V The effect of maternal thrombophilia on placental abruption: Histologic correlates. J. Matern. Fetal Neonatal Med. 2009; 22(3): 243—8.
  33. Lykke J.A., Bare L.A., Olsen J., Lagier R., Arellano A.R., Tong C. et al. Thrombophilias and adverse pregnancy outcomes: results from the Danish National Birth Cohort. J. Thromb. Haemost. 2012; 10(7): 1320—5.
  34. Tam W.H., Ng M.H., Yiu A.K., Lau K.M., Cheng G.Y., Li CY Thrombophilia among Chinese women with venous thromboembolism during pregnancy. Gynecol. Obstet. Invest. 2012; 73(3): 183—8.
  35. Ananth C.V., Nath C.A., Philipp C. The Normal anticoagulant system and risk of placental abruption: protein C, protein S and resistance to activated protein C. J. Matern. Fetal Neonatal Med. 2010; 23(12): 1377—83.
  36. Demir C., Dilek I. Natural coagulation inhibitors and active protein c resistance in preeclampsia. Clinics (Sao Paulo). 2010; 65(11): 1119—22.

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